Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a multicenter, multi-arm, biomarker-stratified trial designed to evaluate biomarker-directed therapies in patients with estrogen receptor-positive/hormone receptor-negative (ER+/HR-) and triple-negative (TN) metastatic breast cancer (MBC). The trial integrates both retrospective and prospective data collection, including archival tumor tissue, medical record abstraction, and prospective tumor and blood sampling prior to initiation of protocol directed treatment. Based on biomarker subtype, participants will receive standard of care therapy. Liquid biopsy will be collected on Cycle 2 Day 1, and then liquid biopsy, imaging and clinical data will be collected at each re-staging. Treatment will continue until discontinuation for progression, toxicity or at the discretion of the treating physician.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Podpisana zgoda na udział w badaniu i pozwolenie na dostęp do danych zdrowotnych
- •Chęć i możliwość uczestniczenia w badaniu zgodnie z oceną lekarza
- •Wiek co najmniej 18 lat
- •Ogólny stan zdrowia oceniony na 0-2 w skali ECOG
- •Spełnienie wszystkich warunków głównego badania LCCC2521
✗ Disqualifies
- •Niemożliwość pobrania próbki z guzów nowotworowych
- •Pacjent już rozpoczął drugą linię leczenia
- •Inne choroby lub stany zdrowia, które mogą uniemożliwić udział w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 23, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (3)
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, United States
Mayo Clinic
Rochester, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, United States
Trial contact
Emily L Schworer
Ana Gallegos
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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