SARS-CoV-2 mRNA Vaccination in Patients With Hepatocellular Carcinoma Treated With Immune Checkpoint Inhibitors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
A multicenter retrospective cohort analysis in Austria Primary Objective: To assess whether receiving an mRNA COVID-19 vaccine within 3 months before starting ICI (Immune checkpoint inhibitors) therapy improves best overall response (mRECIST) in HCC (hepatocellular carcinoma). Secondary Objectives: Evaluate whether vaccination within 1 or 3 months affects OS (overall survival) , PFS (Progression free survival)), or TTP (Time to progression); compare outcomes by vaccination status, vaccine type, and prior infection; explore modification by cirrhosis severity and tumor characteristics; and assess safety (irAEs, steroid use, toxicity-related discontinuation).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony rak wątroby (na podstawie badań obrazowych lub biopsji)
- •Leczenie lekami immunologicznymi (samodzielnie lub w kombinacji, np. atezolizumab, nivolumab, pembrolizumab)
- •Dostępne pełne dane medyczne pacjenta
- •Co najmniej jedno badanie obrazowe pokazujące odpowiedź na leczenie
✗ Disqualifies
- •Brak ważnych danych klinicznych potrzebnych do analizy (np. informacja o przeżyciu, data progresji choroby, klasyfikacja stanu wątroby)
Simplified criteria — AI translation
Trial details
- Last updated (source)
- October 8, 2026
- Sex
- No restrictions
Locations (5)
Medical University of Graz
Graz, Austria
Ordensklinikum Linz
Linz, Austria
University Hospital St. Pölten
Sankt Pölten, Austria
Krankenhaus der Barmherzigen Brüder St Veit an der Glan
Sankt Veit an der Glan, Austria
Klinikum Wels-Grieskirchen
Wels, Austria
Trial contact
Florian Rainer, MD
Vanessa Stadlbauer, Univ. Prof. MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/9/2026.
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