An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.

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This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This is a multicenter, open-label, single-arm study of prophylaxis for Dato-DXd-related stomatitis in eligible patients with metastatic or inoperable locally recurrent breast cancer or locally advanced or metastatic Epidermal Growth Factor Receptor-Mutated (EGFRm) non-small cell lung cancer.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Rozpoznanie zaawansowanego raka piersi (HR+/HER2-) lub zaawansowanego raka płuc (EGFR-mutujący) niepodlegającego operacji
  • Wiek co najmniej 18 lat
  • Wcześniejsze leczenie chemioterapią i/lub terapią celowaną na nowotwór
  • Gotowość do stosowania płynu odkażającego do jamy ustnej (deksametazon) przez cały czas leczenia
  • Dobry stan ogólny (skala ECOG 0-1)
  • Wystarczająca liczba hemoglobiny we krwi (co najmniej 9 g/dL)
  • Ujemny test ciążowy dla kobiet w wieku reprodukcyjnym
  • Zdolność do podpisania świadomej zgody i przestrzegania zasad badania

✗ Disqualifies

  • Wcześniejsze otrzymanie leku Dato-DXd
  • Poważne problemy kardiologiczne, oddechowe, naczyniowe lub nerkami

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 10, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (39)

Research Site

Tucson, United States

Research Site

Hot Springs, United States

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Little Rock, United States

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Duarte, United States

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Glendale, United States

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Lakewood, United States

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Long Beach, United States

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Torrance, United States

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Washington D.C., United States

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Plantation, United States

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Athens, United States

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Boise, United States

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Park Ridge, United States

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Fort Wayne, United States

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Elizabethtown, United States

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Lexington, United States

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Lexington, United States

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Louisville, United States

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New Orleans, United States

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Frederick, United States

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Glenn Dale, United States

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Detroit, United States

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Grayling, United States

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Minneapolis, United States

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Kansas City, United States

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Reno, United States

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Lebanon, United States

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East Syracuse, United States

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Westbury, United States

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White Plains, United States

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Greensboro, United States

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Wilson, United States

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Cleveland, United States

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Wynnewood, United States

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Knoxville, United States

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Fairfax, United States

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Charleston, United States

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Morgantown, United States

Research Site

Waukesha, United States

Trial contact

AstraZeneca Clinical Study Information Center

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/11/2026.

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