Strategic Endocrine Therapy and Targeted Radiotherapy for Prostate Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to study definitive external beam radiation therapy together with drugs called androgen deprivation therapy (ADT) in patients with prostate cancer. The investigators want to find out if these drugs work the same way if they are given for 6 months or for the usual 18 months in patients who receive also definitive external beam radiotherapy. The investigators will also learn about the safety of the treatments. The main questions the study aims to answer are: Do patients who get radiation therapy plus 6 months of androgen deprivation therapy need other hormone therapy or develop castration resistance at a higher rate within 5 years, compared to patients who get radiation therapy plus 18 months of androgen deprivation therapy? Participants will: Be treated with definitive external beam radiation therapy and receive androgen deprivation therapy for 6 months or 18 months. Have visits once every 3 months for checkups and tests for at least 5 years. The visits at 3 months, 1 year, and 5 years need to be done in person; all the other visits can be done in person or remotely (telehealth). Keep a diary of the missed doses of the androgen deprivation therapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowoobecnie adenokarcynoma (rak) prostaty
- •Wysoko zaawansowany rak prostaty ograniczony do miednicy: PSA ≥20 ng/mL, skala Gleasona 8-10, lub stadium kliniczne T3a i wyżej
- •Brak przerzutów potwierdzony badaniami obrazowymi
- •Planowanie leczenia radioterapią i hormonoterapią
- •Wiek co najmniej 18 lat
- •Zdolność do zrozumienia i podpisania zgody na udział w badaniu
- •Gotowość do uczestnictwa w badaniu przez całą jego długość
✗ Disqualifies
- •Przerzuty raka (w węzłach chłonnych poza miednicą lub odległy rozsiał)
- •Wcześniejsza operacja usunięcia prostaty
- •Wcześniejsze leczenie hormonalne raka prostaty (z wyjątkiem rozpoczętego w ciągu 90 dni)
- •Wcześniejsza chemioterapia na raka prostaty
- •Wcześniejsza radioterapia okolicy miednicy
- •Warunki, które mogą zagrażać bezpieczeństwu lub zgodności pacjenta z protokołem badania
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 4, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (1)
University of California San Diego
La Jolla, United States
Trial contact
Tyler Seibert, MD, PhD
Genitourinary Research Team
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/5/2026.
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