A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study will test whether BNT324 is safe and works better against metastatic castration-resistant prostate cancer (mCRPC) than the current standard of care (SoC) chemotherapy, which is docetaxel (given together with the steroid medicines prednisone or prednisolone). The study will include participants with mCRPC that have been previously treated with androgen receptor pathway inhibitor, but with no previous taxane-based systematic chemotherapy for mCRPC. The main goals of this study are: * To find out if BNT324 helps participants live longer without their cancer getting worse (radiographic progression-free survival \[rPFS\]). * To find out if BNT324 helps participants live longer overall (overall survival \[OS\]).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Mężczyzna w wieku co najmniej 18 lat
- •Zaawansowany rak prostaty, który wraca lub rozwija się mimo leczenia
- •Wzrost poziomu PSA lub widoczne zmiany raka w obrazach (tomografia, USG, rezonans)
- •Wcześniejsze leczenie 1-2 lekami hamującymi hormony męskie, bez poprawy
- •Nigdy nie otrzymywał chemioterapii opartej na taksanach w zaawansowanym stadium
- •Poddany kastracji chirurgicznej lub stałe leczenie hormonalne ze zbyt niskim testosteronem
✗ Disqualifies
- •Wcześniejsze leczenie innymi lekami celowanymi na B7-H3
- •Niekontrolowane lub poważne choroby serca
- •Historia chorób płuc (zapalenie tkanki płucnej) wymagającej sterydów
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 20, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (15)
Rocky Mountain Cancer Centers
Aurora, United States
Florida Cancer Specialists- Fort Myers
Fort Myers, United States
Florida Cancer Specialists- St. Petersburg
St. Petersburg, United States
Florida Cancer Specialists- West Palm Beach
West Palm Beach, United States
Illinois Cancer Specialists
Niles, United States
Illinois CancerCare PC
Peoria, United States
Maryland Oncology Hematology
Rockville, United States
Oncology/Hematology Care, Inc.
Cincinnati, United States
SCRI Oncology Partners
Nashville, United States
Texas Oncology South Austin
Austin, United States
Texas Oncology Gulf Coast
Houston, United States
Texas Oncology, P.A. - Tyler
Tyler, United States
Texas Oncology - West Texas
Wichita Falls, United States
Virginia Cancer Specialists PC
Fairfax, United States
Virginia Oncology Associates
Norfolk, United States
Trial contact
BioNTech clinical trials patient information
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/21/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.