Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone therapy plus ribociclib for the treatment of patients with high anatomic stage breast cancer with low risk of the cancer returning (low risk recurrence). Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy, with letrozole, anastrozole or exemestane, lowers the amount of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Hormone therapy plus ribociclib may work as well as chemotherapy followed by hormone therapy plus ribociclib for the treatment of high anatomic stage breast cancer with low recurrence risk.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Dobry stan ogólny (skala ECOG 0-2 w ostatnich 28 dniach)
- •Kobieta po menopauzie lub mężczyzna
- •Zaawansowany nowotwór piersi (określone stadia T i N bez T4)
- •Tumor dodatni na receptor estrogenowy (ER) — powyżej 10% komórek
- •Tumor ujemny na receptor HER2
- •Guzek główny spełnia kryteria kwalifikacyjne (może być wiele guzków)
- •Po usunięciu guza: czysty margines chirurgiczny bez nowotworu (jeśli brzeg tylny dodatni — dozwolony)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 21, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (140)
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, United States
Sutter Auburn Faith Hospital
Auburn, United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, United States
Tower Cancer Research Foundation
Beverly Hills, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
Palo Alto Medical Foundation Health Care
Palo Alto, United States
Sutter Roseville Medical Center
Roseville, United States
Sutter Medical Center Sacramento
Sacramento, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
California Pacific Medical Center-Pacific Campus
San Francisco, United States
Mills Health Center
San Mateo, United States
Ridley-Tree Cancer Center
Santa Barbara, United States
Cedars-Sinai Cancer - Tarzana
Tarzana, United States
Sutter Solano Medical Center/Cancer Center
Vallejo, United States
UCI Health - Yorba Linda
Yorba Linda, United States
Stamford Hospital/Bennett Cancer Center
Stamford, United States
Beebe South Coastal Health Campus
Millville, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
Beebe Health Campus
Rehoboth Beach, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
SIH Cancer Institute
Carterville, United States
Illinois CancerCare-Carthage
Carthage, United States
Northwestern University
Chicago, United States
Northwestern Medicine Cancer Center Old Irving Park
Chicago, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Decatur Memorial Hospital
Decatur, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, United States
Illinois CancerCare-Eureka
Eureka, United States
Illinois CancerCare-Galesburg
Galesburg, United States
Northwestern Medicine Cancer Center Delnor
Geneva, United States
Northwestern Medicine Glenview Outpatient Center
Glenview, United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, United States
Northwestern Medicine Huntley Hospital
Huntley, United States
Illinois CancerCare-Kewanee Clinic
Kewanee, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, United States
Illinois CancerCare-Macomb
Macomb, United States
Northwestern Medicine McHenry Hospital
McHenry, United States
SSM Health Good Samaritan
Mount Vernon, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
HSHS Saint Elizabeth's Hospital
O'Fallon, United States
Northwestern Medicine Oak Brook
Oak Brook, United States
Northwestern Medicine Orland Park
Orland Park, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Illinois CancerCare-Princeton
Princeton, United States
Southern Illinois University School of Medicine
Springfield, United States
Springfield Clinic
Springfield, United States
Springfield Memorial Hospital
Springfield, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, United States
Illinois CancerCare - Washington
Washington, United States
Mary Greeley Medical Center
Ames, United States
McFarland Clinic - Ames
Ames, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
Saint Anthony Regional Hospital
Carroll, United States
Mercy Hospital
Cedar Rapids, United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, United States
McFarland Clinic - Marshalltown
Marshalltown, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
UM Upper Chesapeake Hematology and Oncology - Aberdeen
Aberdeen, United States
University of Maryland/Greenebaum Cancer Center
Baltimore, United States
Greater Baltimore Medical Center
Baltimore, United States
UM Upper Chesapeake Medical Center
Bel Air, United States
University of Maryland Shore Medical Center at Easton
Easton, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, United States
Essentia Health Saint Joseph's Medical Center
Brainerd, United States
Essentia Health - Deer River Clinic
Deer River, United States
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, United States
Essentia Health Cancer Center
Duluth, United States
Miller-Dwan Hospital
Duluth, United States
Essentia Health Hibbing Clinic
Hibbing, United States
Abbott-Northwestern Hospital
Minneapolis, United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, United States
Regions Hospital
Saint Paul, United States
United Hospital
Saint Paul, United States
Essentia Health Sandstone
Sandstone, United States
Saint Francis Regional Medical Center
Shakopee, United States
Essentia Health Virginia Clinic
Virginia, United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, United States
Baptist Cancer Center-Grenada
Grenada, United States
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, United States
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, United States
Saint Francis Medical Center
Cape Girardeau, United States
Parkland Health Center - Farmington
Farmington, United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, United States
Missouri Baptist Medical Center
St Louis, United States
Missouri Baptist Sullivan Hospital
Sullivan, United States
Billings Clinic Cancer Center
Billings, United States
Bozeman Health Deaconess Hospital
Bozeman, United States
Benefis Sletten Cancer Institute
Great Falls, United States
Community Medical Center
Missoula, United States
Jefferson Cherry Hill Hospital
Cherry Hill, United States
Sidney Kimmel Cancer Center Washington Township
Sewell, United States
Roswell Park Cancer Institute
Buffalo, United States
Mount Sinai Chelsea
New York, United States
Mount Sinai West
New York, United States
Mount Sinai Hospital
New York, United States
Good Samaritan University Hospital
West Islip, United States
Southeastern Medical Oncology Center-Clinton
Clinton, United States
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, United States
Essentia Health Cancer Center-South University Clinic
Fargo, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Thomas Jefferson University Hospital
Philadelphia, United States
Jefferson Torresdale Hospital
Philadelphia, United States
Asplundh Cancer Pavilion
Willow Grove, United States
Lexington Medical Center
West Columbia, United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, United States
Duluth Clinic Ashland
Ashland, United States
Northwest Wisconsin Cancer Center
Ashland, United States
Essentia Health-Hayward Clinic
Hayward, United States
Cancer Center of Western Wisconsin
New Richmond, United States
Essentia Health-Spooner Clinic
Spooner, United States
Essentia Health Saint Mary's Hospital - Superior
Superior, United States
Doctors Cancer Center
Manati, Puerto Rico
Centro Comprensivo de Cancer de UPR
San Juan, Puerto Rico
PROncology
San Juan, Puerto Rico
San Juan City Hospital
San Juan, Puerto Rico
Trial contact
Site Public Contact
Elizabeth John
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kristie A. Bobolis
PRINCIPAL_INVESTIGATOR
Site Public Contact
Yuan Yuan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ritesh Parajuli
PRINCIPAL_INVESTIGATOR
Site Public Contact
Helen K. Chew
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
K.M. S. Lo
PRINCIPAL_INVESTIGATOR
Site Public Contact
Gregory A. Masters
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
John M. Schallenkamp
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bryan A. Faller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Lisa E. Flaum
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Jay W. Carlson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Joseph J. Merchant
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Seema Harichand-Herdt
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Deborah W. Wilbur
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Richard L. Deming
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Katherine H. Tkaczuk
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Priyanka Mittar
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Elie G. Dib
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bret E. Friday
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
David M. King
PRINCIPAL_INVESTIGATOR
Site Public Contact
Donald J. Jurgens
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Elena Shagisultanova
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ellis G. Levine
PRINCIPAL_INVESTIGATOR
Site Public Contact
Anupama Goel
PRINCIPAL_INVESTIGATOR
Site Public Contact
Meytal Fabrikant
PRINCIPAL_INVESTIGATOR
Site Public Contact
Samer S. Kasbari
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Nerea Lopetegui-Lia
PRINCIPAL_INVESTIGATOR
Site Public Contact
Steven A. Madden
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Luis J. Santos Reyes
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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