Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone therapy plus ribociclib for the treatment of patients with high anatomic stage breast cancer with low risk of the cancer returning (low risk recurrence). Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy, with letrozole, anastrozole or exemestane, lowers the amount of estrogen made by the body. This may help stop the growth of tumor cells that need estrogen to grow. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Hormone therapy plus ribociclib may work as well as chemotherapy followed by hormone therapy plus ribociclib for the treatment of high anatomic stage breast cancer with low recurrence risk.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Dobry stan ogólny (skala ECOG 0-2 w ostatnich 28 dniach)
- •Kobieta po menopauzie lub mężczyzna
- •Zaawansowany nowotwór piersi (określone stadia T i N bez T4)
- •Tumor dodatni na receptor estrogenowy (ER) — powyżej 10% komórek
- •Tumor ujemny na receptor HER2
- •Guzek główny spełnia kryteria kwalifikacyjne (może być wiele guzków)
- •Po usunięciu guza: czysty margines chirurgiczny bez nowotworu (jeśli brzeg tylny dodatni — dozwolony)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (36)
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, United States
Stamford Hospital/Bennett Cancer Center
Stamford, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
SIH Cancer Institute
Carterville, United States
Illinois CancerCare-Carthage
Carthage, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Decatur Memorial Hospital
Decatur, United States
Illinois CancerCare-Eureka
Eureka, United States
Illinois CancerCare-Galesburg
Galesburg, United States
Illinois CancerCare-Kewanee Clinic
Kewanee, United States
Illinois CancerCare-Macomb
Macomb, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
HSHS Saint Elizabeth's Hospital
O'Fallon, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Illinois CancerCare-Princeton
Princeton, United States
Southern Illinois University School of Medicine
Springfield, United States
Springfield Clinic
Springfield, United States
Springfield Memorial Hospital
Springfield, United States
Illinois CancerCare - Washington
Washington, United States
Mercy Hospital
Cedar Rapids, United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, United States
Mercy Medical Center - Des Moines
Des Moines, United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, United States
Baptist Cancer Center-Grenada
Grenada, United States
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, United States
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, United States
Bozeman Health Deaconess Hospital
Bozeman, United States
Community Medical Center
Missoula, United States
Lexington Medical Center
West Columbia, United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, United States
Trial contact
Site Public Contact
Elizabeth John
PRINCIPAL_INVESTIGATOR
Site Public Contact
K.M. S. Lo
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bryan A. Faller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Deborah W. Wilbur
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Richard L. Deming
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
John M. Schallenkamp
PRINCIPAL_INVESTIGATOR
Site Public Contact
Steven A. Madden
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.