KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study will test an experimental drug called KQB198 in combination with imatinib. The goal is to determine if this combination is safe and tolerable and assess how effective the combination is at treating GIST. Imatinib has been approved by the FDA for the treatment of different types of cancer including GIST.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Nowotwór nie do operacji lub rozprzestrzeniony na inne części ciała
- •Potwierdzony rozpoznaniem GIST na podstawie badania tkanki
- •Wynik testu genetycznego potwierdzający mutację KIT (bez mutacji w exonie 9) lub mutację PDGFRA (bez mutacji D842V)
- •Mierzalne zmiany chorobowe widoczne w badaniach obrazowych
- •Pierwszy etap leczenia zaawansowanego lub rozprzestrzenionego raka; wcześniejsze leczenie imatynibu dopuszczalne tylko jeśli skończyło się ponad rok temu
- •Prawidłowa funkcja narządów wewnętrznych i ogólny stan zdrowia pozwalający na uczestnictwo
✗ Disqualifies
- •Niezdolność do połykania lub choroby żołądka/jelit uniemożliwiające wchłanianie leku
- •Inne aktywne nowotwory w ciągu ostatnich 2 lat
- •Uczulenie na składniki leku KQB198 lub imatynib
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (16)
USC Norris Comprehensive Cancer Center
Los Angeles, United States
Mayo Clinic - Jacksonville
Jacksonville, United States
Sylvester Comprehensive Cancer Center
Miami, United States
Moffitt Cancer Center
Tampa, United States
University of Chicago Medical Center
Chicago, United States
University of Iowa Health Care
Iowa City, United States
Dana-Farber Cancer Institute
Boston, United States
University of Michigan Hospitals
Ann Arbor, United States
Mayo Clinic - Rochester
Rochester, United States
Northwell Health/R.J. Zuckerberg Cancer Center
Lake Success, United States
University of North Carolina at Chapel Hill
Chapel Hill, United States
Cleveland Clinic
Cleveland, United States
Oregon Health & Science University
Portland, United States
UT MD Anderson Cancer Center
Houston, United States
Huntsman Cancer Institute
Salt Lake City, United States
Fred Hutchinson Cancer Center
Seattle, United States
Trial contact
Kumquat Clinical Development
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/9/2026.
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