A Phase III Study of HMPL-760 Plus R-GemOx VS Placebo Plus R-GemOx in Relapsed/Refractory DLBCL
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase III randomized, double-blind, positive controlled study to evaluate the efficacy, safety, and pharmacokinetics of HMPL-760 in combination with R-GemOx versus placebo in combination with R-GemOx in patients with R/R DLBCL.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub starszy
- •Potwierdzony badaniem mikroskopowym rozlany chłoniak B-komórkowy z dużych komórek
- •Pacjent powinien mieć zmianę widoczną w badaniach obrazowych, którą można zmierzyć
- •Ogólny stan zdrowia pozwalający na otrzymanie leczenia (ocena ECOG 0-2)
- •Oczekiwana długość przeżycia co najmniej 12 tygodni
- •Zgodę na uczestnictwo w badaniu i zdolność do wypełniania wymogów protokołu
✗ Disqualifies
- •Chłoniak w centralnym układzie nerwowym lub objawy mogące wskazywać na jego obecność
- •Ciąża lub karmienie piersią
- •Znaczne uszkodzenie wątroby, nerek lub innych narządów
- •Aktywna infekcja HIV, wirusem zapalenia wątroby B lub C
- •Krwawienia w ostatnich 8 tygodniach (z przewodu pokarmowego, mózgu lub płuc)
- •Zaburzenia krzepnięcia krwi lub przyjmowanie leków rozrzedzających krew (warfaryna)
- •Pozostałe działania niepożądane z poprzedniego leczenia przeciwnowotworowego (poza wypadaniem włosów)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 20, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (50)
Fudan University Shanghai Cancer Center
Shanghai, China
Baoding NO.1 Central Hospital
Baoding, China
Beijing GoBroad Hospital
Beijing, China
BEIJING TONGREN HOSPITAL, Capital Medical University
Beijing, China
The First Affiliated Hospital of Bengbu Medical College
Bengbu, China
The First Hospital of Jilin University
Changchun, China
Hunan Cancer Hospital
Changsha, China
People's Hospital of Hunan Province
Changsha, China
The Second Xiangya Hospital of Central South University
Changsha, China
Sichuan Provincial People's Hospital
Chengdu, China
West China Hospital of Sichuan University
Chengdu, China
Chongqing University Cancer Hospital
Chongqing, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
Quanzhou First Hospital.Fujian
Fujian, China
Fujian Medical University Union Hospital
Fuzhou, China
Guangdong Provincial People's Hospital
Guangzhou, China
Sun Yat-sen University Cancer Center
Guangzhou, China
ZhuJiang Hospital of Southern Medical University（The Second Clinical Medical College）
Guangzhou, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, China
The First Affiliated Hospital, Zhejiang University
Hangzhou, China
Zhejiang Cancer Hospital
Hangzhou, China
Harbin Medical University Cancer Hospital
Harbin, China
The Second Affiliated Hospital of Anhui Medical University
Hefei, China
Qilu Hospital of Shandong University
Jinan, China
Shandong Cancer Hospital & Institute
Jinan, China
The First Affiliated Hospital of Kunming Medical University
Kunming, China
Jiangxi Cancer Hospital
Nanchang, China
Jiangsu Cancer Hospital
Nanjing, China
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Nanjing, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, China
The Affiliated Hospital of Qingdao University
Qingdao, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China
Tongji Hospital of Tongji University
Shanghai, China
Shengjing Hospital of China Medical University
Shenyang, China
Shenzhen people's hospital
Shenzhen, China
Shanxi Provincial Cancer Hospital
Taiyuan, China
North China University of Science and Technology Affiliated Hospital
Tangshan, China
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Tianjin, China
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Tianjin People's Hospital
Tianjin, China
People's Hospital of Xinjiang Uygur Autonomous Region
Ürümqi, China
The First Affiliated Hospital of WMU
Wenzhou, China
Hubei Cancer Hospital
Wuhan, China
Wuhan Union Hospital of China
Wuhan, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hosiptal)
Xi'an, China
The First Affiliated Hospital of Xiamen University
Xiamen, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China
Henan Cancer Hospital
Zhengzhou, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Trial contact
Dongmei Chen, CPL
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/21/2026.
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