A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers are looking for new ways to treat locally advanced or metastatic urothelial cancer (UC). Current treatments for locally advanced or metastatic UC include chemotherapy, immunotherapy, and targeted therapy. Researchers want to know if giving sacituzumab tirumotecan (sac-TMT), the trial medicine, can treat locally advanced or metastatic UC that got worse after certain treatments. The goal of this trial is to learn if people who receive sac-TMT live longer than those who receive certain non-platinum chemotherapies.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak pęcherza moczowego, który rozprzestrzenił się lub jest zaawansowany, ale nie nadaje się do leczenia operacyjnego ani napromieniania mającego na celu wyleczenie.
- •Choroba jest widoczna w badaniach obrazowych.
- •Otrzymano już pewne leczenia, w tym immunoterapię (anty-PD-(L)1), chemioterapię zawierającą platynę oraz lek enfortumab vedotin.
- •Otrzymano maksymalnie 2 wcześniejsze linie leczenia.
- •Choroba nasiliła się po ostatnim zastosowanym leczeniu.
- •Ogólny stan zdrowia pozwala na udział w badaniu (w skali 0-1).
✗ Disqualifies
- •Problemy z oczami, które mogą utrudniać gojenie się rogówki.
- •Nieustabilizowane lub poważne problemy zdrowotne.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 13, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (105)
Sibley Memorial Hospital ( Site 0849)
Washington D.C., United States
Emory University Hospital ( Site 0824)
Atlanta, United States
Johns Hopkins University ( Site 0843)
Baltimore, United States
Dana Farber Cancer Institute ( Site 0783)
Boston, United States
Munson Medical Center ( Site 0812)
Traverse City, United States
Morristown Memorial Hospital ( Site 0795)
Morristown, United States
Memorial Sloan Kettering Cancer Center ( Site 0832)
New York, United States
WakeMed Raleigh Campus ( Site 0811)
Raleigh, United States
TriHealth Cancer Institute-Good Samaritan Hospital ( Site 0822)
Cincinnati, United States
Cleveland Clinic - Ohio ( Site 0793)
Cleveland, United States
Fox Chase Cancer Center ( Site 0830)
Philadelphia, United States
The West Clinic, P.C. ( Site 0791)
Germantown, United States
Thompson Cancer Survival Center ( Site 0803)
Knoxville, United States
Tennessee Oncology, PLLC - Elliston Place Plaza Medical Oncology & Hematology ( Site 0831)
Nashville, United States
Virginia Oncology Associates (VOA) ( Site 8002)
Norfolk, United States
Fred Hutchinson Cancer Research Center ( Site 0787)
Seattle, United States
Hospital Italiano de Buenos Aires ( Site 0004)
Ciudad Autonoma de Buenos Aires, Argentina
Asociacion de Beneficencia Hospital Sirio Libanes ( Site 0003)
Ciudad Autonoma de Buenos Aires, Argentina
Instituto Alexander Fleming ( Site 0002)
Ciudad Autónoma de Buenos Aires, Argentina
Instituto de Oncologia de Rosario ( Site 0005)
Rosario, Argentina
Macquarie University ( Site 0031)
Macquarie, Australia
Mater Hospital Brisbane ( Site 0032)
South Brisbane, Australia
Cliniques Universitaires Saint-Luc ( Site 0062)
Brussels, Belgium
AZ Maria Middelares ( Site 0063)
Ghent, Belgium
UZ Gent ( Site 0064)
Ghent, Belgium
CHC Montlegia Clinic ( Site 0061)
Liège, Belgium
ICTRIALS Pesquisa e Desenvolvimento ( Site 0107)
Curitiba, Brazil
Hospital Moinhos de Vento ( Site 0102)
Porto Alegre, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0110)
São José do Rio Preto, Brazil
Hospital Alemao Oswaldo Cruz ( Site 0101)
São Paulo, Brazil
Princess Margaret Cancer Centre ( Site 0123)
Toronto, Canada
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0121)
Québec, Canada
Peking University First Hospital ( Site 0184)
Beijing, China
The First Affiliated Hospital of Chonqing Medical University ( Site 0197)
Chongqing, China
Sun Yat-Sen University Cancer Center ( Site 0183)
Guangzhou, China
Sun Yat-Sen University Cancer Center ( Site 0188)
Guangzhou, China
Zhujiang Hospital of Southern Medical University ( Site 0205)
Guangzhou, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Urology Surgery ( Site 0189)
Guangzhou, China
The Fifth Affiliated Hospital of Sun Yat-Sen University ( Site 0900)
Zhuhai, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0198)
Wuhan, China
The Second Xiangya Hospital of Central South University ( Site 0916)
Changsha, China
Jiangsu Cancer Hospital ( Site 0917)
Nanjing, China
Jiangxi Cancer Hospital ( Site 0192)
Nanchang, China
Fudan University Shanghai Cancer Center ( Site 0181)
Shanghai, China
Zhongshan Hospital Fudan University ( Site 0907)
Shanghai, China
West China Hospital of Sichuan University ( Site 0185)
Chengdu, China
The Second Hospital of Tianjin Medical University ( Site 0910)
Tianjin, China
The First Hospital of Jiaxing ( Site 0901)
Jiaxing, China
The First Affiliated Hospital of Ningbo University ( Site 0193)
Ningbo, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 0186)
Wenzhou, China
The First Affiliated Hospital of Wenzhou Medical University ( Site 0194)
Wenzhou, China
CHRU de Brest ( Site 0272)
Brest, France
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0304)
Berlin, Germany
General Oncology Hospital of Kifisia "Agioi Anargyroi" ( Site 0335)
Athens, Greece
METROPOLITAN GENERAL HOSPITAL-ONCOLOGIC CLINICAL TRIALS AND RESEARCH CLINIC ( Site 0332)
Athens, Greece
University General Hospital ''Attikon'' - General Hospital of West Attica "H AGIA VARVARA" ( Site 0333)
Chaïdári, Greece
Athens Medical Center ( Site 0336)
Marousi, Greece
European Interbalkan Medical Center ( Site 0331)
Thessaloniki, Greece
Rambam Health Care Campus ( Site 0362)
Haifa, Israel
Shaare Zedek Medical Center ( Site 0366)
Jerusalem, Israel
Rabin Medical Center ( Site 0364)
Petah Tikva, Israel
Sheba Medical Center ( Site 0361)
Ramat Gan, Israel
Yitzhak Shamir Medical Center. ( Site 0367)
Ẕerifin, Israel
Istituto Clinico Humanitas ( Site 0398)
Rozzano, Italy
Azienda Ospedaliera S. Luigi Gonzaga ( Site 0391)
Orbassano, Italy
Centro Ricerche Cliniche di Verona ( Site 0393)
Verona, Italy
Ospedale San Donato. Azienda Sanitaria Toscana Sud Est ( Site 0392)
Arezzo, Italy
IRCCS Azienda Ospedaliera Metropolitana ( Site 0394)
Genova, Italy
Fondazione IRCCS Istituto Nazionale Dei Tumori ( Site 0396)
Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 0397)
Roma, Italy
Nagoya University Hospital ( Site 0429)
Nagoya, Japan
Hirosaki University Hospital ( Site 0435)
Hirosaki, Japan
Ehime University Hospital ( Site 0430)
Tōon, Japan
Hokkaido University Hospital ( Site 0436)
Sapporo, Japan
Kobe University Hospital ( Site 0431)
Kobe, Japan
University of Tsukuba Hospital ( Site 0432)
Tsukuba, Japan
Kagawa University Hospital ( Site 0424)
Kita-gun, Japan
St. Marianna University Hospital ( Site 0422)
Kawasaki, Japan
Kitasato University Hospital ( Site 0425)
Sagamihara, Japan
Nara Medical University Hospital ( Site 0423)
Kashihara, Japan
Osaka Rosai Hospital ( Site 0428)
Sakai, Japan
Institute of Science Tokyo Hospital ( Site 0421)
Bunkyo, Japan
Cancer Institute Hospital of JFCR ( Site 0426)
Koto, Japan
Kyushu University Hospital ( Site 0434)
Fukuoka, Japan
Gifu University Hospital ( Site 0427)
Gifu, Japan
Kyoto University Hospital ( Site 0433)
Kyoto, Japan
Radboudumc ( Site 0487)
Nijmegen, Netherlands
Maastricht UMC+ ( Site 0483)
Maastricht, Netherlands
Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 0482)
Amsterdam, Netherlands
Elisabeth-TweeSteden Ziekenhuis ( Site 0489)
Tilburg, Netherlands
Isala, locatie Zwolle ( Site 0486)
Zwolle, Netherlands
Erasmus Medisch Centrum ( Site 0481)
Rotterdam, Netherlands
St. Antonius Ziekenhuis, locatie Utrecht ( Site 0488)
Utrecht, Netherlands
H. de Badalona Germans Trias I Pujol ( Site 0603)
Badalona, Spain
Hospital Universitario Marques de Valdecilla ( Site 0605)
Santander, Spain
Hospital Universitario Insular de Gran Canaria ( Site 0604)
Las Palmas de Gran Canaria, Spain
Hospital Universitario Ramon y Cajal ( Site 0606)
Madrid, Spain
Hospital Universitari Vall d Hebron ( Site 0607)
Barcelona, Spain
Hospital Clinico San Carlos ( Site 0608)
Madrid, Spain
Hospital Universitario 12 de Octubre ( Site 0602)
Madrid, Spain
Hospital Virgen del Rocio ( Site 0601)
Seville, Spain
Laenssjukhuset Ryhov ( Site 0632)
Jönköping, Sweden
Karolinska Universitetssjukhuset Solna ( Site 0631)
Stockholm, Sweden
Cambridge University Hospitals NHS Foundation Trust ( Site 0756)
Cambridge, United Kingdom
St Bartholomew's Hospital ( Site 0751)
London, United Kingdom
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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