Effectiveness of a Vaginal Gel on CIN1/2 Regression and HPV Clearance.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to evaluate whether a Coriolus versicolor-based vaginal gel facilitates HPV clearance in women aged 30-50 years diagnosed with HPV and CIN1 or CIN2. In addition, the study will investigate whether the gel promotes regression of CIN1/CIN2, assessment of patient satisfaction, treatment compliance and characterize the vaginal microbiome. The primary outcomes therefore is: • hrHPV clearance from baseline to follow-up (6 months) In this randomized controlled study, eligible participants will be randomized 1:1 into two groups: 1. Intervention group: Women (n=35) will apply a CV-based vaginal gel (Papilocare®) daily for 21 days for 3 months. Afterward, the gel should be used every other day for an additional 3 months. Every month includes a 7-day break due to menstruation (28 days cycle). 2. Control group; Women (n=35) will follow the conventional "wait and see" approach.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 30-50 lat
- •Pozytywny test na HPV z potwierdzonym przedrakowymizmianami szyjki macicy (stadium 1 lub 2)
- •Kwalifikuje się do obserwacyjnego leczenia bez interwencji
- •Rozumiesz język duński pisany i mówiony
✗ Disqualifies
- •Jesteś w ciąży lub karmiąc piersią
- •Nienormalne krwawienia z pochwy
- •Osłabiona lub zaburzona odporność
- •Cukrzyca
- •Usunięta macica w przeszłości
- •Aktualny nowotwór lub historia zmian zaawansowanych w okolicy genitalnej w ciągu 5 lat
Simplified criteria — AI translation
Trial details
- Minimum age
- 30 Years
- Maximum age
- 50 Years
- Last updated (source)
- August 3, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (2)
Department of Gynaecology and Obstetrics
Horsens, Denmark
Department of Gynaecology and Obstetrics
Randers, Denmark
Trial contact
Pinar Bor, Professor, MD, Ph.D.
Vibe M Bertelsen, Post.Doc, MD, Ph.D.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/4/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.