Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to evaluate the efficacy and safety of sonesitatug vedotin in combination with capecitabine with or without rilvegostomig in first-line (1L) Claudin18.2 (CLDN18.2)-positive, human epidermal growth factor receptor 2 (HER2)-negative, gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent rozumie badanie i wyraża na nie zgodę.
- •Pacjent ma ukończone 18 lat.
- •Pacjent ma nieoperacyjnego, zaawansowanego miejscowo lub z przerzutami raka żołądka, połączenia przełykowo-żołądkowego lub dolnej części przełyku, który nie był wcześniej leczony.
- •W komórkach raka stwierdzono obecność białka CLDN18.2.
- •Stan ogólny pacjenta pozwala na aktywne uczestnictwo w badaniu (ECOG 0 lub 1).
- •Oczekiwana długość życia pacjenta wynosi co najmniej 12 tygodni.
- •Istnieje co najmniej jedna zmiana chorobowa, którą lekarz może ocenić.
- •Pacjent ma prawidłowe wyniki badań krwi i narządów.
✗ Disqualifies
- •Rak pacjenta jest HER2-pozytywny.
- •Pacjent ma aktywne lub leczone wrzody żołądka lub krwawienia z żołądka.
- •Pacjent ma chorobę autoimmunologiczną lub zapalną wymagającą leczenia lekami sterydowymi lub immunosupresyjnymi.
- •Pacjent ma przerzuty do mózgu.
- •Pacjent ma znaczący płyn w jamie opłucnej lub brzusznej, który wymaga drenażu.
- •Pacjent wymaga żywienia pozajelitowego z powodu niedrożności żołądka lub jelit.
- •Pacjent ma objawy neuropatii obwodowej (uszkodzenie nerwów).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (286)
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Mobile, United States
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Anchorage, United States
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Phoenix, United States
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Springdale, United States
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Duarte, United States
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Fullerton, United States
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La Jolla, United States
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Los Alamitos, United States
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Orange, United States
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Walnut Creek, United States
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Denver, United States
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Lone Tree, United States
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New Haven, United States
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Newark, United States
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Washington D.C., United States
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Fort Myers, United States
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Jacksonville, United States
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Orlando, United States
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St. Petersburg, United States
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West Palm Beach, United States
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Atlanta, United States
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Atlanta, United States
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Atlanta, United States
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Macon, United States
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Newnan, United States
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Chicago, United States
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Niles, United States
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Zion, United States
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Indianapolis, United States
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Waukee, United States
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Lexington, United States
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Louisville, United States
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Boston, United States
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Burlington, United States
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Worcester, United States
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Grand Rapids, United States
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Burnsville, United States
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Duluth, United States
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Rochester, United States
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Kansas City, United States
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St Louis, United States
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Camden, United States
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East Brunswick, United States
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Hackensack, United States
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New Brunswick, United States
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Summit, United States
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New York, United States
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New York, United States
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New York, United States
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The Bronx, United States
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The Bronx, United States
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White Plains, United States
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Charlotte, United States
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Wilmington, United States
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Winston-Salem, United States
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Cleveland, United States
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Columbus, United States
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Portland, United States
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Portland, United States
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Hershey, United States
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Philadelphia, United States
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Pittsburgh, United States
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Pittsburgh, United States
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Wilkes-Barre, United States
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York, United States
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Charleston, United States
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Sioux Falls, United States
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Memphis, United States
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Nashville, United States
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Dallas, United States
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Dallas, United States
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Sherman, United States
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Blacksburg, United States
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Fairfax, United States
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Falls Church, United States
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Fort Belvoir, United States
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Richmond, United States
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Edmonds, United States
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Issaquah, United States
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Olympia, United States
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Seattle, United States
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Charleston, United States
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Milwaukee, United States
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Darlinghurst, Australia
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Garran, Australia
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Heidelberg, Australia
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Murdoch, Australia
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Randwick, Australia
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Westmead, Australia
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Linz, Austria
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Rankweil, Austria
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Vienna, Austria
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Wiener Neustadt, Austria
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Brussels, Belgium
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Edegem, Belgium
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Ghent, Belgium
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Leuven, Belgium
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Barretos, Brazil
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Fortaleza, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Salvador, Brazil
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Santa Maria, Brazil
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São Paulo, Brazil
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Vitória, Brazil
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Edmonton, Canada
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Abbotsford British Columbia, Canada
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Vancouver, Canada
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Winnipeg, Canada
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Moncton, Canada
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Barrie, Canada
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Brampton, Canada
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Ottawa, Canada
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Sault Ste. Marie, Canada
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Toronto, Canada
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Toronto, Canada
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Montreal, Canada
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Québec, Canada
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Beijing, China
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Beijing, China
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Beijing, China
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Beijing, China
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Changde, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Fuzhou, China
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Fuzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Hohhot, China
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Jinan, China
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Kunming, China
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Lanzhou, China
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Linhai, China
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Linyi, China
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Nanchang, China
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Nanchang, China
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Nanjing, China
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Nanjing, China
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Nanning, China
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Nantong, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shantou, China
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Shenyang, China
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Shenzhen, China
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Tianjin, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Xiamen, China
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Xingtai, China
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Xuzhou, China
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Yinchuan, China
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Zhengzhou, China
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Bordeaux, France
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Caen, France
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Lyon, France
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Marseille, France
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Rennes, France
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Villejuif, France
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Augsburg, Germany
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Bad Saarow, Germany
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Berlin, Germany
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Bonn, Germany
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Dresden, Germany
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Essen, Germany
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Essen, Germany
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Frankfurt, Germany
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Freiburg im Breisgau, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Heilbronn, Germany
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Leipzig, Germany
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Lichtenberg, Germany
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Magdeburg, Germany
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Mainz, Germany
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Mannheim, Germany
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Marburg, Germany
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Minden, Germany
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Moers, Germany
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München, Germany
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Stuttgart, Germany
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Ulm, Germany
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Budapest, Hungary
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Budapest, Hungary
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Debrecen, Hungary
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Győr, Hungary
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Gyula, Hungary
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Nyíregyháza, Hungary
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Pécs, Hungary
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Zalaegerszeg, Hungary
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Ahmedabad, India
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Bhubaneswar, India
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Hyderabad, India
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Mohali, India
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Mohali, India
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Mumbai, India
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New Delhi, India
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New Delhi, India
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Varanasi, India
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Vijayawada, India
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Visakhapatnam, India
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Meldola, Italy
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Milan, Italy
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Milan, Italy
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Milan, Italy
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Padova, Italy
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Rozzano, Italy
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Tricase, Italy
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Bunkyō City, Japan
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Chūōku, Japan
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Hirakata-shi, Japan
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Kashiwa, Japan
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Kitaadachi-gun, Japan
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Kōtoku, Japan
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Kurashiki-shi, Japan
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Nagoya, Japan
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Niigata, Japan
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Osaka, Japan
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Ota-shi, Japan
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Sagamihara-shi, Japan
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Sakai, Japan
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Sendai, Japan
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Shimotsuke-shi, Japan
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Sunto-gun, Japan
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Yokohama, Japan
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Yokohama, Japan
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Groningen, Netherlands
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Rotterdam, Netherlands
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Tilburg, Netherlands
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Gdansk, Poland
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Koszalin, Poland
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Krakow, Poland
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Lublin, Poland
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Olsztyn, Poland
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Warsaw, Poland
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San Juan, Puerto Rico
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Daegu, South Korea
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Hwasun-gun, South Korea
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Seongnam-si, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Barcelona, Spain
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Barcelona, Spain
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Madrid, Spain
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Pamplona, Spain
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Santander, Spain
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Santiago de Compostela, Spain
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Valencia, Spain
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Kaohsiung City, Taiwan
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Dusit, Thailand
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Hat Yai, Thailand
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Khon Kaen, Thailand
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Muang, Thailand
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Muang, Thailand
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Ankara, Turkey (Türkiye)
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Antalya, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Medreseboğazı, Turkey (Türkiye)
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Şahinbey, Turkey (Türkiye)
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Cambridge, United Kingdom
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Dundee, United Kingdom
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Leeds, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Oxford, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.