MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a phase 3, randomized, double-blind study of adjuvant calderasib plus subcutaneous pembrolizumab and berahyaluronidase alfa (MK-3475A) versus adjuvant placebo plus MK-3475a in participants with completely resected stage IIA-IIIB (N2), KRAS G12C-mutant non-small cell lung cancer following receipt of either neoadjuvant pembrolizumab plus chemotherapy or adjuvant chemotherapy. The primary goal of the study is to compare adjuvant calderasib plus MK-3475A to adjuvant placebo plus MK-3475A with respect to disease-free survival (DFS) as assessed by the investigator.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak płuc (NSCLC), który nie jest rakiem drobnokomórkowym i spełnia określone kryteria stadium (IIA-IIIB).
- •Rak płuc został całkowicie usunięty chirurgicznie.
- •W tkance guza wykryto specyficzną zmianę genetyczną (mutację KRAS G12C).
- •Od zakończenia leczenia przedoperacyjnego lub chemioterapii pooperacyjnej minęło nie więcej niż 12 tygodni.
- •Badania obrazowe po operacji nie wykazały oznak choroby.
✗ Disqualifies
- •Inny typ raka płuc niż rak płaski (np. rak drobnokomórkowy) lub obecność innych typów komórek w guzie.
- •Niektóre inne choroby towarzyszące lub przebyte, które mogą wpłynąć na bezpieczeństwo lub skuteczność leczenia.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 24, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (72)
Instituto Alexander Fleming ( Site 0310)
Ciudad Autónoma de Buenos Aires, Argentina
Sanatorio Parque ( Site 0311)
Rosario, Argentina
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0306)
CABA, Argentina
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0309)
CABA, Argentina
Northern Beaches Hospital ( Site 3009)
Frenchs Forest, Australia
Moncton Hospital ( Site 0200)
Moncton, Canada
Centre Hospitalier de l'Université de Montréal ( Site 0219)
Montreal, Canada
Peking Union Medical College Hospital ( Site 2105)
Beijing, China
Chongqing University Three Gorges Hospital ( Site 2138)
Chongqing, China
The First Affiliated Hospital Of Fujian Medical University ( Site 2123)
Fuzhou, China
Sun Yat-sen University Cancer Center ( Site 2134)
Guangzhou, China
Guangxi Medical University Cancer Hospital ( Site 2115)
Nanning, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 2139)
Wuhan, China
Xiangya Hospital Central South University ( Site 2136)
Changsha, China
Shanghai Pulmonary Hospital ( Site 2125)
Shanghai, China
Sichuan Cancer hospital ( Site 2101)
Chengdu, China
The Third Peoples Hospital Of Chengdu ( Site 2141)
Chengdu, China
Yunnan Province Cancer Hospital ( Site 2131)
Kunming, China
The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 2103)
Hangzhou, China
Ningbo No. 2 Hospital ( Site 2124)
Ningbo, China
Centre de Cancérologie du Grand Montpellier ( Site 1016)
Montpellier, France
Evangelismos General Hospital of Athens ( Site 1204)
Athens, Greece
Errikos Dunant Hospital Center ( Site 1201)
Athens, Greece
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA" ( Site 1206)
Athens, Greece
Athens Medical Center ( Site 1202)
Athens, Greece
Metaxa Cancer Hospital of Piraeus ( Site 1207)
Piraeus, Greece
G. Papanikolaou General Hospital ( Site 1203)
Thessaloniki, Greece
Queen Mary Hospital ( Site 3100)
Hong Kong, Hong Kong
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1400)
Milan, Italy
National Cancer Center ( Site 3603)
Goyang-si, South Korea
The Catholic University of Korea St. Vincent s Hospital ( Site 3602)
Suwon, South Korea
Keimyung University Dongsan Hospital ( Site 3605)
Daegu, South Korea
Severance Hospital Yonsei University Health System ( Site 3601)
Seoul, South Korea
Asan Medical Center ( Site 3600)
Seoul, South Korea
Hospital Insular de Gran Canaria ( Site 1704)
Las Palmas de Gran Canaria, Spain
Institut Català d'Oncologia (ICO) - Girona ( Site 1703)
Girona, Spain
Hospital Puerta de Hierro ( Site 1705)
Majadahonda, Spain
Hospital Universitari Vall d'Hebron ( Site 1700)
Barcelona, Spain
Hospital Clinico San Carlos ( Site 1706)
Madrid, Spain
Hospital Universitario la Paz ( Site 1710)
Madrid, Spain
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1707)
Madrid, Spain
H.R.U Malaga - Hospital General ( Site 1708)
Málaga, Spain
Hospital Universitario Virgen Macarena ( Site 1709)
Seville, Spain
Taipei Medical University Shuang Ho Hospital ( Site 3700)
New Taipei City, Taiwan
National Cheng Kung University Hospital ( Site 3706)
Tainan, Taiwan
Mackay Memorial Hospital ( Site 3701)
Taipei, Taiwan
Tri-Service General Hospital ( Site 3708)
Taipei, Taiwan
Baskent University Dr. Turgut Noyan Research and Training Center ( Site 1812)
Adana, Turkey (Türkiye)
Adana Medical Park Seyhan Hastanesi ( Site 1827)
Adana, Turkey (Türkiye)
Ankara Atatürk Sanatoryum Eğitim ve Araştırma Hastanesi ( Site 1825)
Ankara, Turkey (Türkiye)
Hacettepe Universite Hastaneleri ( Site 1810)
Ankara, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi ( Site 1811)
Ankara, Turkey (Türkiye)
Liv Hospital Ankara ( Site 1828)
Ankara, Turkey (Türkiye)
Kartal Lütfi Kırdar Şehir Hastanesi ( Site 1826)
Istanbul, Turkey (Türkiye)
İnönü Üniversitesi Turgut Özal Tıp Merkezi ( Site 1815)
Malatya, Turkey (Türkiye)
Mersin Sehir Eğitim ve Araştırma Hastanesi ( Site 1824)
Mersin, Turkey (Türkiye)
Recep Tayyip Erdogan University Training and Research Hospital ( Site 1816)
Rize, Turkey (Türkiye)
Sakarya Egitim ve Arastırma Hastanesi ( Site 1817)
Sakarya, Turkey (Türkiye)
COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 1904)
Cherkasy, Ukraine
Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 1909)
Chernivtsi, Ukraine
Medical Center "Mriya Med-Service" ( Site 1911)
Kryvyi Rih, Ukraine
Communal Non-Commercial Enterprise Prykarpatski Clinical Oncological Center of Ivano-Frankivsk Regio ( Site 1900)
Ivano-Frankivsk, Ukraine
Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 1916)
Kropyvnytskyi, Ukraine
Ukrainian Center of Tomotherapy ( Site 1917)
Kropyvnytskyi, Ukraine
Communal noncommercial enterprise of Lviv regional council "Lviv oncological regional therapeutical ( Site 1908)
Lviv, Ukraine
Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 1902)
Lviv, Ukraine
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 1913)
Odesa, Ukraine
ME "Rivne Regional Antitumor Center" Rivne Regional Council ( Site 1912)
Rivne, Ukraine
Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 1903)
Vinnytsia, Ukraine
Municipal Enterprise "Volyn Regional Clinical Hospital" of Volyn Regional Council ( Site 1914)
Lutsk, Ukraine
Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 1915)
Kyiv, Ukraine
Shalimov Institute of Surgery and Transplantation ( Site 1907)
Kyiv, Ukraine
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/8/2026.
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