DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This clinical trial is looking at two drugs called dabrafenib and trametinib. Dabrafenib and trametinib are approved as standard of care treatment for adult patients with melanoma (a type of skin cancer) or lung cancer and in children with glioma (a type of brain tumour). This means they have gone through clinical trials and been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK. Dabrafenib and trametinib work in patients with a particular mutation in their cancer known as BRAF V600. Investigators now wish to find out if they will be useful in treating patients with other cancer types which have the same mutation. If the results are positive, the study team will work with the NHS and the Cancer Drugs Fund to see if these drugs can be routinely accessed for patients in the future. This trial is part of a trial programme called DETERMINE. The programme will also look at other anti-cancer drugs in the same way, through matching the drug to rare cancer types or ones with specific mutations.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowotwór z mutacją BRAF V600 (łącznie z histiocytozą komórek Langerhansa)
- •Wiek co najmniej 1 rok i waga co najmniej 8 kg
- •Kobiety w wieku rozrodczym muszą mieć ujemny test ciąży i stosować bezpieczną antykoncepcję niehormonalną (spiralę, ligację jajowodów lub wazektomię partnera)
- •Karmiące matki muszą przerwać karmienie piersią na czas leczenia
Simplified criteria — AI translation
Trial details
- Minimum age
- 1 Year
- Last updated (source)
- August 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (27)
Belfast City Hospital
Belfast, United Kingdom
University Hospital Birmingham
Birmingham, United Kingdom
Birmingham Children's Hospital
Birmingham, United Kingdom
Bristol Royal Hospital for Children
Bristol, United Kingdom
Bristol Haematology and Oncology Centre
Bristol, United Kingdom
Addenbrooke's Hospital
Cambridge, United Kingdom
Velindre Cancer Centre
Cardiff, United Kingdom
Cardiff Children's Hospital
Cardiff, United Kingdom
Western General Hospital
Edinburgh, United Kingdom
The Beatson Hospital
Glasgow, United Kingdom
Royal Hospital for Children Glasgow
Glasgow, United Kingdom
Leicester Royal Infirmary
Leicester, United Kingdom
Alder Hey Hospital
Liverpool, United Kingdom
University College London Hospital
London, United Kingdom
Guy's Hopsital
London, United Kingdom
Great Ormond Street Hospital
London, United Kingdom
Royal Manchester Children's Hospital
Manchester, United Kingdom
The Christie Hospital
Manchester, United Kingdom
Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, United Kingdom
Great North Children's Hospital
Newcastle, United Kingdom
Freeman Hospital
Newcastle, United Kingdom
Churchill Hospital
Oxford, United Kingdom
John Radcliffe Hospital
Oxford, United Kingdom
Weston Park Hospital
Sheffield, United Kingdom
Sheffield's Children's Hospital
Sheffield, United Kingdom
Southampton General Hospital
Southampton, United Kingdom
The Royal Marsden Hospital
Sutton, United Kingdom
Trial contact
Aida Sarmiento Castro
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/18/2026.
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