RecruitingPhase IIIEN originalHead and neck cancer

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This phase III trial compares cetuxumab to chemotherapy, carboplatin and paclitaxel, with intensity modulated radiation therapy for the treatment of patients with head and neck cancer who are unable to receive cisplatin. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of cancer cells. This may help keep cancer cells from growing. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Intensity modulated radiation therapy is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. It is not yet know if cetxiumab or chemotherapy, with intensity modulated radiation therapy works best for the treatment of patients with head and neck cancer who are unable to receive cisplatin.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony mikroskopowo rak płaskonabłonkowy głowy i szyi (gardła, krtani, farynksu dolnego lub jamy ustnej), który wcześniej nie był leczony
  • Nowotwór w zaawansowanym stadium (nie rozprzestrzenil się na odległe narządy, ale zajmuje duży obszar)
  • Dla pacjentów z rakiem gardła: przeprowadzony test na białko p16
  • Pacjent nie może otrzymać cisplatyny (lek podstawowy w tym leczeniu)
  • Nowotwór nie był wcześniej operacyjnie usunięty

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
August 17, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (63)

Tower Cancer Research Foundation

Beverly Hills, United States

USC / Norris Comprehensive Cancer Center

Los Angeles, United States

Cedars-Sinai Medical Center

Los Angeles, United States

Helen F Graham Cancer Center

Newark, United States

Medical Oncology Hematology Consultants PA

Newark, United States

Christiana Care Health System-Christiana Hospital

Newark, United States

Christiana Care Health System-Wilmington Hospital

Wilmington, United States

Bay Pines VA Healthcare System

Bay Pines, United States

OSF Saint Joseph Medical Center

Bloomington, United States

Illinois CancerCare-Bloomington

Bloomington, United States

Illinois CancerCare-Canton

Canton, United States

Illinois CancerCare-Carthage

Carthage, United States

Northwestern University

Chicago, United States

Cancer Care Specialists of Illinois - Decatur

Decatur, United States

Decatur Memorial Hospital

Decatur, United States

Illinois CancerCare-Eureka

Eureka, United States

Illinois CancerCare-Galesburg

Galesburg, United States

Northwestern Medicine Glenview Outpatient Center

Glenview, United States

Northwestern Medicine Grayslake Outpatient Center

Grayslake, United States

Illinois CancerCare-Kewanee Clinic

Kewanee, United States

Northwestern Medicine Lake Forest Hospital

Lake Forest, United States

Illinois CancerCare-Macomb

Macomb, United States

Cancer Care Center of O'Fallon

O'Fallon, United States

HSHS Saint Elizabeth's Hospital

O'Fallon, United States

Northwestern Medicine Orland Park

Orland Park, United States

Illinois CancerCare-Ottawa Clinic

Ottawa, United States

Illinois CancerCare-Pekin

Pekin, United States

Illinois CancerCare-Peoria

Peoria, United States

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, United States

OSF Saint Francis Medical Center

Peoria, United States

Illinois CancerCare-Peru

Peru, United States

Illinois CancerCare-Princeton

Princeton, United States

Illinois CancerCare - Washington

Washington, United States

Mercy Hospital

Cedar Rapids, United States

Oncology Associates at Mercy Medical Center

Cedar Rapids, United States

University of Kansas Cancer Center

Kansas City, United States

University of Kansas Cancer Center-Overland Park

Overland Park, United States

University of Kansas Hospital-Indian Creek Campus

Overland Park, United States

University of Kansas Health System Saint Francis Campus

Topeka, United States

University of Kansas Hospital-Westwood Cancer Center

Westwood, United States

University of Kentucky/Markey Cancer Center

Lexington, United States

The James Graham Brown Cancer Center at University of Louisville

Louisville, United States

UofL Health Medical Center Northeast

Louisville, United States

Saint Francis Medical Center

Cape Girardeau, United States

University of Kansas Cancer Center - Briarcliff

Kansas City, United States

University of Kansas Cancer Center - North

Kansas City, United States

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, United States

Stony Brook University Medical Center

Stony Brook, United States

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, United States

ProMedica Flower Hospital

Sylvania, United States

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, United States

University of Cincinnati Cancer Center-West Chester

West Chester, United States

Christiana Care Health System-Concord Health Center

Chadds Ford, United States

Aspirus Cancer Care-Antigo-Volm Cancer Center

Antigo, United States

Froedtert Menomonee Falls Hospital

Menomonee Falls, United States

Medical College of Wisconsin

Milwaukee, United States

Froedtert and MCW Moorland Reserve Health Center

New Berlin, United States

Drexel Town Square Health Center

Oak Creek, United States

Aspirus Cancer Care-Rhinelander-James Beck Cancer Center

Rhinelander, United States

Aspirus Cancer Care - Stevens Point

Stevens Point, United States

Aspirus Cancer Care-Wausau

Wausau, United States

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, United States

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, United States

Trial contact

Zachary S. Zumsteg

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jacob S. Thomas

PRINCIPAL_INVESTIGATOR

Gregory A. Masters

PRINCIPAL_INVESTIGATOR

Ryan J. Burri

PRINCIPAL_INVESTIGATOR

Bryan A. Faller

PRINCIPAL_INVESTIGATOR

Laila A. Gharzai

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Deborah W. Wilbur

PRINCIPAL_INVESTIGATOR

Site Public Contact

Christopher Lominska

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Susanne M. Arnold

PRINCIPAL_INVESTIGATOR

Site Public Contact

Rebecca A. Redman

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Achuta K. Guddati

PRINCIPAL_INVESTIGATOR

Kerri McGovern

PRINCIPAL_INVESTIGATOR

Ahmed G. Elsayed

PRINCIPAL_INVESTIGATOR

Andrew J. Huang

PRINCIPAL_INVESTIGATOR

Site Public Contact

Musaddiq J. Awan

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/18/2026.

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