A Study of Nuzefatide Pevedotin (BT5528) in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase 2 study for nuzefatide pevedotin (BT5528) in adults with a specific type of pancreatic cancer called metastatic pancreatic ductal adenocarcinoma (PDAC) that has spread and worsened after one previous treatment. The drug, nuzefatide pevedotin (nuzefatide), is designed to find a specific protein called EphA2. The main aims of the study are to see how well the drug works against the tumor (efficacy), what side effects it may have (safety), and how the body processes it (pharmacokinetics). All participants in this study will receive nuzefatide, and both they and their doctors will know what is being administered (single-arm, open-label). The trial will take place at several different medical centers.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Osoby w wieku 18 lat lub starsze.
- •Potwierdzony rak trzustki (typ PDAC), który się rozprzestrzenił.
- •Choroba jest widoczna w badaniach obrazowych.
- •Stan ogólny pacjenta pozwala na leczenie (nie jest zbyt osłabiony).
- •Przewidywana długość życia co najmniej 12 tygodni.
- •Pacjent przyjmował tylko jedno wcześniejsze leczenie na ten typ raka.
- •Dostępna tkanka guza do badań.
- •Dobre wyniki podstawowych badań narządów (krew, nerki, wątroba).
✗ Disqualifies
- •Chemioterapia lub radioterapia w ciągu ostatnich 14 dni.
- •Inne leczenie eksperymentalne w ciągu ostatnich 28 dni.
- •Wcześniejsze leczenie niektórymi lekami (np. taksanami) na raka trzustki lub lekami zawierającymi MMAE.
- •Objawy toksyczności po wcześniejszym leczeniu nie ustąpiły do łagodnego stopnia.
- •Zmiany w mózgu (przerzuty) wymagające leczenia.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 30, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (3)
Siteman Cancer Center (Washington University School of Medicine)
St Louis, United States
Memorial Sloan Kettering Cancer Center - Main Campus
New York, United States
Thomas Jefferson University, Sidney Kimmel Comprensive Cancer Center, Clinical Trials Office
Philadelphia, United States
Trial contact
BicycleTx Limited
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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