Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares temporally-modulated pulsed radiation therapy versus standard radiation therapy in treating patients with newly diagnosed, IDH wildtype, MGMT-unmethylated glioblastoma. After completion of surgery, the standard of care for glioblastoma is radiation therapy. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. For older and frail patients, standard treatment also includes the chemotherapy drug temozolomide. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's DNA and may kill tumor cells and slow down or stop tumor growth. Approximately 70% of glioblastoma patients have MGMT-unmethylated status. MGMT unmethylated tumors are less likely to respond to temozolomide chemotherapy, so there is more reliance on radiation therapy to kill the tumor cells. Recent clinical trials studying new therapies for MGMT-unmethylated glioblastoma have failed to improve outcomes over temozolomide. These recent studies also indicate that 80% of patients experience a decline in memory and thinking function after treatment. TMPRT differs from standard radiation therapy by delivering the same amount of radiation dose in 10-13 "pulses" with 3-minute breaks between pulses. TMPRT with temozolomide may work better than standard radiation therapy with temozolomide in increasing survival, as well as improving memory and thinking function in patients with newly diagnosed, IDH wildtype, MGMT-unmethylated glioblastoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Nowo rozpoznany gleјak mózgu bez mutacji IDH
- •Potwierdzenie zabiegu chirurgicznego z wystarczającą ilością tkanki do badań
- •Tkanka wysłana do centralnego laboratorium w ciągu 30 dni od operacji
- •Brak rozsiania nowotworu poza mózg
- •Ujemny wynik testu ciąży (u osób w wieku rozrodczym)
- •Biegłość w języku angielskim
✗ Disqualifies
- •Mutacja IDH potwierdzona w badaniach
- •Rozsianie nowotwo do opon mózgowo-rdzeniowych lub poza mózg
- •Biopsia stereotaktyczna bez pełnego wycięcia guza
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (54)
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
USC / Norris Comprehensive Cancer Center
Los Angeles, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
Saint Mary's Hospital and Regional Medical Center
Grand Junction, United States
Alton Memorial Hospital
Alton, United States
Decatur Memorial Hospital
Decatur, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, United States
Northwestern Medicine Cancer Center Delnor
Geneva, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
HSHS Saint Elizabeth's Hospital
O'Fallon, United States
Memorial Hospital East
Shiloh, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
Saint Anthony Regional Hospital
Carroll, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
UI Healthcare Mission Cancer and Blood - Pella
Pella, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
University of Kansas Cancer Center
Kansas City, United States
University of Kansas Cancer Center-Overland Park
Overland Park, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
Maryland Proton Treatment Center
Baltimore, United States
University of Maryland/Greenebaum Cancer Center
Baltimore, United States
UM Upper Chesapeake Medical Center
Bel Air, United States
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
University of Kansas Cancer Center - Briarcliff
Kansas City, United States
University of Kansas Cancer Center - North
Kansas City, United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Renown Regional Medical Center
Reno, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, United States
Montefiore Medical Center-Einstein Campus
The Bronx, United States
Montefiore Medical Center-Weiler Hospital
The Bronx, United States
Montefiore Medical Center - Moses Campus
The Bronx, United States
Case Western Reserve University
Cleveland, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
ThedaCare Regional Cancer Center
Appleton, United States
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, United States
Medical College of Wisconsin
Milwaukee, United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, United States
Drexel Town Square Health Center
Oak Creek, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, United States
Trial contact
Site Public Contact
Xiao-Tang Kong
PRINCIPAL_INVESTIGATOR
Site Public Contact
Adam Garsa
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ruben C. Fragoso
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lucas Gilbride
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jiayi Huang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bryan A. Faller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Vinai Gondi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Seema Harichand-Herdt
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Danielle Cunningham
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mark V. Mishra
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Mohamed Abdelhakiem
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Suchit H. Patel
PRINCIPAL_INVESTIGATOR
Site Public Contact
Tony J. Wang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Justin Tang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Haley K. Perlow
PRINCIPAL_INVESTIGATOR
Site Public Contact
Shearwood McClelland
PRINCIPAL_INVESTIGATOR
Site Public Contact
Joseph A. Bovi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Brett A. Morris
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael W. Straza
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/10/2026.
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