HERizon-Breast: A ctDNA-Guided Adaptive Study of Sequential Anti-HER2 Therapies and CNS Prophylaxis to Induce Long-Term Remission
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Thie purpose of this study is to find out whether a personalized treatment approach-using a series of ctDNA tests along with standard imaging scans to help decide when to step up (escalate) or decrease (de-escalate) sequential treatments (given one after another)-combined with local therapies (which treat cancer in a specific part of the body) and treatments that prevent cancer from spreading to the central nervous system (CNS; including the brain and spinal cord) can result in long-lasting remission and possibly cure some participants with HER2+ metastatic breast cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat z potwierdzonym histologicznie rakiem piersi, który nie poddaje się operacji lub jest zaawansowany.
- •Rak w stadium IV (nowo wykryty, już ze zmianami przerzutowymi) w momencie diagnozy.
- •Wynik HER2 3+ w badaniu immunohistochemicznym.
- •Spodziewana długość życia co najmniej 12 tygodni.
- •Zdolność do operacji chirurgicznej lub możliwość jej przeprowadzenia po leczeniu wstępnym.
- •Możliwość zmierzenia choroby w badaniach obrazowych.
- •Stan ogólny pacjenta oceniony na 0-1 w skali ECOG (pełna lub prawie pełna sprawność).
- •Zadowalające funkcje narządów wewnętrznych (wątroba, nerki, serce) potwierdzone badaniami z ostatnich 14 dni.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- May 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (7)
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
Basking Ridge, United States
Memorial Sloan Kettering at Monmouth (Limited Protocol Activities)
Middletown, United States
Memorial Sloan Kettering at Bergen (Limited Protocol Activities)
Montvale, United States
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)
Commack, United States
Memorial Sloan Kettering at Westchester (Limited Protocol Activities)
Harrison, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activites)
New York, United States
Memorial Sloan Kettering at Nassau (Limited Protocol Activities)
Uniondale, United States
Trial contact
Pedram Razavi, MD, PhD
Atif Khan, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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