Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
GENCONCOR-2 is a translational research aimed to compare the molecular profile of primary tumors and their matched brain metastases in gastroesophageal cancers, including cancer of the esophagus, gastroesophageal junction, and stomach. The study is based on the previously established international GASTROBRAIN cohort (ClinicalTrials.gov ID: NCT07448493), which provides comprehensive clinicopathological and treatment data for over 230 patients. It will be conducted by retrospective analysis of paired samples of histological material (primary tumor and corresponding brain metastasis) with determination of HER2 expression status (IHC ± FISH), MSI status (IHC ± PCR), PD-L1 combined positive score (CPS), and CLDN18.2 expression status (IHC)
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Uczestnik wcześniejszego badania GASTROBRAIN
- •Potwierdzony histologicznie rak żołądka lub przełyku
- •Przebyta operacja usunięcia przerzutów z mózgu z dostępnym materiałem tkankowym
- •Dostępne próbki tkankowe zarówno z pierwotnego nowotworu, jak i z przerzutu w mózgu
✗ Disqualifies
- •Wiele odrębnych nowotworów w innych narządach niż żołądek lub przełyk
- •Nowotwór pierwszy poza przewodem pokarmowym
- •Nowotwory niebłonnikowe (np. guzy neuroendokrynne, mięsaki)
- •Przerzuty tylko w kościach czaszki bez zajęcia samego mózgu
- •Zbyt mała ilość lub słaba jakość próbki tkankowej do badań
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 5, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Blokhin's Russian Cancer Research Center
Moscow, Russia
Trial contact
David Khalafyan, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/6/2026.
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