A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is an open-label, multicenter Phase 2 study evaluating BMS-986504 in participants with advanced and/or metastatic solid tumors that have MTAP deletion. The study includes a monotherapy component and a combination component in which BMS-986504 is given with other anti-cancer agents. The trial will assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of BMS-986504 alone and in combination regimens.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowotwór w stadium zaawansowanym lub z przerzutami, z uszkodzonym genem MTAP.
- •Choroba postępująca mimo wcześniejszego leczenia, lub brak możliwości zastosowania innego leczenia.
- •Pacjent musi mieć widoczne zmiany nowotworowe do zmierzenia.
- •W dobrej ogólnej kondycji zdrowotnej (parametr ECOG 0 lub 1).
✗ Disqualifies
- •Nie można wcześniej przyjmować leków wpływających na PRMT5 lub MAT2A.
- •Brak aktywnego raka mózgu lub zapalenia opon mózgowych na tle nowotworowym (chyba że został skutecznie wyleczony).
- •Nie można mieć problemów z jelitami w ciągu ostatnich 6 miesięcy, które mogłyby wpływać na wchłanianie leków.
- •Zapewnione prawidłowe funkcjonowanie narządów (np. wątroby, nerek).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (58)
Local Institution - 0096
San Francisco, United States
Local Institution - 0182
Aurora, United States
Emory University - Winship Cancer Institute
Atlanta, United States
Johns Hopkins Hospital
Baltimore, United States
Local Institution - 0124
Boston, United States
Local Institution - 0119
Ann Arbor, United States
Local Institution - 0129
Rochester, United States
Local Institution - 0174
Rochester, United States
Local Institution - 0181
Rochester, United States
Local Institution - 0142
Buffalo, United States
Local Institution - 0170
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Local Institution - 0100
Durham, United States
University of Texas MD Anderson Cancer Center
Houston, United States
Local Institution - 0086
Seattle, United States
Local Institution - 0134
Madison, United States
UZ Brussel
Brussels, Belgium
Cliniques universitaires Saint-Luc
Brussels, Belgium
UZ Gent
Ghent, Belgium
Local Institution - 0051
Vancouver, Canada
Local Institution - 0021
Toronto, Canada
Local Institution - 0007
Toronto, Canada
Local Institution - 0155
Beijing, China
Local Institution - 0185
Chongqing, China
Local Institution - 0184
Guangzhou, China
The First Affiliated Hospital of Henan Medical University
Xinxiang, China
Shanghai GoBroad Cancer Hospital China Pharmaceutical University
Shanghai, China
Fudan University Shanghai Cancer Center
Shanghai, China
Local Institution - 0078
Dijon, France
Local Institution - 0075
Pierre-Bénite, France
Local Institution - 0116
Villejuif, France
Hôpital Saint-Louis
Paris, France
Local Institution - 0081
Mainz, Germany
Universitaetsklinikum Hamburg
Hamburg, Germany
Local Institution - 0039
Heidelberg, Germany
Universitaetsklinikum Leipzig
Leipzig, Germany
Klinikum Rechts der Isar der Technischen Universitaet Muenchen
München, Germany
Local Institution - 0047
Würzburg, Germany
Local Institution - 0150
Hksar, Hong Kong
Local Institution - 0063
Shatin, Hong Kong
Cork University Hospital
Cork, Ireland
Mater Misericordiae University Hospital (MMUH)
Dublin, Ireland
Local Institution - 0146
Dublin, Ireland
Local Institution - 0073
Siena, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
Bergamo, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, Italy
Hospital Santa Maria della Misericordia in Perugia
Perugia, Italy
National Cancer Center Hospital
Chuo-ku, Japan
Haukeland Universitetssjukehus
Bergen, Norway
Oslo Universitetssykehus HF, Ullevål
Oslo, Norway
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Local Institution - 0068
Barcelona, Spain
Local Institution - 0071
Hospitalet, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Trial contact
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
First line of the email MUST contain NCT # and Site #.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/31/2026.
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