A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers are looking for new ways to treat 2 types of non-Hodgkin lymphoma (NHL) called follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). FL is a slow-growing type of NHL. DLBCL is a fast-growing type of NHL. NHL is a cancer in the lymphatic system that causes swollen lymph nodes. The lymphatic system is part of the immune system. In this study, researchers want to learn if MK-1045 can treat FL and DLBCL. MK-1045 is a study treatment that is an immunotherapy, which helps the immune system fight cancer. The goals of this study are to learn how safe MK-1045 is and if people tolerate it. Researchers also want to see if FL and DLBCL respond (the cancer gets smaller or goes away) to treatment.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Choroba nawróciła lub nie zareagowała na co najmniej 2 wcześniejsze leczenia.
- •Potwierdzona diagnoza chłoniaka grudkowego lub chłoniaka rozlanego z dużych komórek B.
- •W przypadku chłoniaka rozlanego z dużych komórek B: progresja choroby po leczeniu CAR-T lub niemożność jego przeprowadzenia.
- •Posiadanie próbki guza.
- •W przypadku wcześniejszego leczenia celowanego w CD19: udokumentowane zachowanie białka CD19 w guzie po progresji choroby.
- •Dobrze kontrolowany wirus HIV przy leczeniu lekami antyretrowirusowymi.
- •Wykrywalna wirusowa ilość HBV lub HCV przy leczeniu lekami przeciwwirusowymi.
✗ Disqualifies
- •Przeszczep narządu wewnętrznego.
- •Istniejące lub przebyte choroby ośrodkowego układu nerwowego.
- •Historia poważnych chorób serca lub naczyń mózgowych.
- •Szpiczak z ostrym lub przewlekłym odrzuceniem przeszczepu lub wymagający leczenia immunosupresyjnego.
- •Infekcja HIV z historią mięsaka Kaposiego lub choroby Castlemana.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 14, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (34)
Colorado Blood Cancer Institute ( Site 7000)
Denver, United States
SCRI Oncology Partners ( Site 0100)
Nashville, United States
Instituto Alexander Fleming ( Site 1404)
Ciudad Autonoma de Buenos Aires, Argentina
Sanatorio Nuestra Senora del Rosario ( Site 1403)
Rosario, Argentina
Townsville University Hospital ( Site 0204)
Townsville, Australia
Box Hill Hospital ( Site 0202)
Box Hill, Australia
Princess Margaret Cancer Centre ( Site 0301)
Toronto, Canada
Beijing Cancer hospital ( Site 1701)
Beijing, China
Sun Yat-Sen University Cancer Center ( Site 1712)
Guangzhou, China
Carmel Hospital ( Site 0602)
Haifa, Israel
Shaare Zedek Medical Center ( Site 0603)
Jerusalem, Israel
Haddasah Medical Center ( Site 0600)
Jerusalem, Israel
Sheba Medical Center ( Site 0601)
Ramat Gan, Israel
Sourasky Medical Center. ( Site 0604)
Tel Aviv, Israel
Istituto Nazionale Tumori IRCCS Fondazione Pascale-SC Ematologia Oncologica ( Site 0700)
Campania, Italy
INOC - Istituto Nazionale Oncologico Candiolo ( Site 0701)
Candiolo, Italy
Istituto Europeo di Oncologia IRCCS ( Site 0702)
Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli ( Site 0705)
Roma, Italy
Pratia MCM Krakow ( Site 0903)
Krakow, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( Site 0900)
Warsaw, Poland
Pratia Onkologia Katowice ( Site 0902)
Katowice, Poland
The Catholic University of Korea, Yeouido St. Mary's Hospital ( Site 0801)
Seoul, South Korea
Institut Català d'Oncologia (ICO) - Badalona ( Site 1103)
Badalona, Spain
Hospital Virgen de la Victoria ( Site 1104)
Málaga, Spain
Hospital Universitari Vall de Hebron ( Site 1102)
Barcelona, Spain
Hospital Universitario Gregorio Maranon ( Site 1101)
Madrid, Spain
Hospital Universitario 12 de Octubre ( Site 1105)
Madrid, Spain
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1000)
Ankara, Turkey (Türkiye)
Antalya Egitim ve Arastirma Hastanesi ( Site 1003)
Antalya, Turkey (Türkiye)
Koç Üniversitesi Hastanesi ( Site 1001)
Istanbul, Turkey (Türkiye)
Medipol Mega Universite Hastanesi ( Site 1002)
Istanbul, Turkey (Türkiye)
Samsun Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi ( Site 1005)
Samsun, Turkey (Türkiye)
Derriford Hospital ( Site 1304)
Plymouth, United Kingdom
The Christie NHS Foundation Trust ( Site 1300)
Manchester, United Kingdom
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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