A Study of Ivonescimab in Combination With Dato-DXd or Osimertinib in People With Non-Small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The researchers are doing this study to find out whether ivonescimab in combination with datopotamab deruxtecan- (Dato-DXd) or osimertinib are safe and effective treatments in people with non-small cell lung cancer (NSCLC) that has an EGFR mutation. The researchers will test different doses of the Dato-DXd or osimertinib with an unchanging (fixed) dose of ivonescimab to find the best dose that causes few or mild side effects in participants. Once the dose is found the researchers will test ivonescimab with Dato-DXd or osimertinib in a new group of participants to see if it is effective in treating their NSCLC with an EGFR mutation.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Diagnoza zaawansowanego raka płuc potwierdzona biopsją
- •Obecność mutacji EGFR w komórkach raka lub we krwi
- •Wcześniejsze leczenie innymi lekami na EGFR i chemioterapią
- •Wiek co najmniej 18 lat
- •Ogólny stan zdrowia pozwalający na uczestnictwo (aktywność codziennych czynności)
- •Prawidłowe funkcjonowanie wątroby, nerek i innych ważnych organów
- •Zdolność do połykania tabletek (dla niektórych grup)
- •Zadowalająca liczba komórek krwi
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 13, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (7)
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, United States
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, United States
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
Commack, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, United States
Memorial Sloan Kettering Nassau (All Protocol Activities)
Uniondale, United States
Trial contact
Helena Yu, MD
Gregory Riely, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/14/2026.
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