A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study aims to address the unmet medical need of participants with metastatic colorectal cancer (mCRC) who have previously been treated with irinotecan, oxaliplatin, a fluoropyrimidine, and bevacizumab, by demonstrating an overall survival prolongation with precemtabart tocentecan (Precem-TcT) as single agent or Precem-TcT in combination with bevacizumab compared to trifluoride/tipiracil (FTD-TPI) plus bevacizumab.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnoza zaawansowanego raka jelita grubego
- •Pacjent wcześniej otrzymywał określone leki (irinotekan, oksaliplatynę, fluoropirymidinę) i choroba się pogorszyła lub nie tolerował leczenia
- •Maksymalnie 2 poprzednie linie leczenia w przypadku zaawansowanego nowotworu
- •Dobry ogólny stan zdrowia (skala ECOG 0 lub 1)
- •Zdolność połykania tabletek doustnych
✗ Disqualifies
- •Niepowstrzymane efekty uboczne z wcześniejszych terapii
- •Historia innego nowotworu w ciągu ostatnich 3 lat
- •Przerzuty do mózgu
- •Perforacja lub przesączenie przewodu pokarmowego w ciągu ostatnich 6 miesięcy
- •Niedrożność jelit, niezowiniętość jelit lub zapalenie jelit (wrzodziejące zapalenie jelita grubego, choroba Crohna)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 8, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (92)
Rocky Mountain Cancer Centers, LLP- Aurora
Lone Tree, United States
Florida Cancer Specialists-Broadway
Fort Myers, United States
Florida Cancer Specialists - St. Petersburg Bayfront
St. Petersburg, United States
Florida Cancer Specialists East - FCS EAST - West Palm Beach
West Palm Beach, United States
Illinois Cancer Specialists
Arlington Heights, United States
Illinois CancerCare PC
Peoria, United States
Springfield Clinic
Springfield, United States
Profound Research LLC at Cancer and Leukemia Center
Sterling Heights, United States
Minnesota Oncology Hematology, P.A.
Saint Louis Park, United States
Missouri Cancer Associates - 150518964
Columbia, United States
White Plains Hospital Medical and Wellness PRIME
White Plains, United States
SCRI Oncology Partners
Nashville, United States
Texas Oncology, P.A. - Abilene - 300210366
Abilene, United States
Texas Oncology-South Austin
Austin, United States
Texas Oncology DFW
Bedford, United States
Texas Oncology- San Antonio
San Antonio, United States
Texas Oncology, P.A. - Tyler
Tyler, United States
Virginia Oncology Associates
Newport News, United States
Blue Ridge Cancer Care - 300202915
Roanoke, United States
Instituto de Oncologia de Rosario
Rosario, Argentina
Investigaciones Clinicas Moleculares ICM
Ciudad Autonoma Buenos Aires, Argentina
Centro Oncologico de Excelencia
San Juan, Argentina
Centro de Investigaciones Medicas Tucuman
San Miguel de Tucumán, Argentina
GenesisCare North Shore (Oncology)
St Leonards, Australia
Icon Cancer Centre Chermside
Chermside, Australia
Mater Misericordiae Ltd - PARENT
South Brisbane, Australia
Flinders Medical Centre
Bedford Park, Australia
LKH - Universitätsklinikum der PMU Salzburg - Innere Med III/Hämatologie und Onkologie
Salzburg, Austria
Cliniques Universitaires Saint-Luc - STL
Brussels, Belgium
Grand Hospital de Charleroi - PARENT
Charleroi, Belgium
UZA - Account 3
Edegem, Belgium
UZ Leuven
Leuven, Belgium
The Ottawa Hospital Cancer Centre
Ottawa, Canada
University Health Network - Princess Margaret Cancer Centre
Toronto, Canada
Peking Union Medical College Hospital
Beijing, China
Sun Yat-sen University Cancer Center
Guangzhou, China
Guangxi Medical University Cancer Hospital
Nanning, China
The University of Hong Kong - 1
Hong Kong, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, China
Jiangsu Province Hospital
Nanjing, China
Fudan University Shanghai Cancer Center
Shanghai, China
Sichuan Cancer Hospital
Chengdu, China
The Second Affiliated Hospital of Zhejiang University School of Medicine - 300173725
Hangzhou, China
Institut Bergonié - Service d'Oncologie Médicale
Bordeaux, France
Hopital Claude Huriez - CHU Lille - service d'oncologie medicale
Lille, France
CHU Saint Etienne - Hôpital Nord - Service de Gastro-Entérologie et Hépatologie
Saint Priest En Jarez, France
Centre Leon Berard - Service d'Oncologie Medicale
Lyon, France
Institut Gustave Roussy - Pathologies Digestives
Villejuif, France
Groupe Hospitalier Pitie-Salpetriere - Service Hépato-Gastro-Entérologie
Paris, France
Krankenhaus Nordwest GmbH - Neurologische Klinik
Frankfurt am Main, Germany
Universitaetsklinikum Leipzig AoeR - Universitaeres Krebszentrum Leipzig (UCCL)
Leipzig, Germany
Haematologisch-Onkologische Praxis Eppendorf (HOPE)
Hamburg, Germany
The Chinese University of Hong Kong (CUHK) - Prince of Wales Hospital (PWH)
Hong Kong, Hong Kong
IEO Istituto Europeo di Oncologia - Divisione Oncologia Medica
San Giovanni Rotondo, Italy
Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli" - Dipartimento di Oncologia
Naples, Italy
Istituto Nazionale Tumori Fondazione G. Pascale - Dipartimento Oncoematologia
Naples, Italy
Azienda Ospedaliero Universitaria Pisana - U.O. Oncologia II
Pisa, Italy
Aichi Cancer Center Hospital
Nagoya, Japan
NHO Kyushu Cancer Center - 300175822
Fukuoka, Japan
Kanagawa Cancer Center - Dept of Gastroenterology
Yokohama, Japan
Kindai University Hospital
Sakai-shi, Japan
Saitama Cancer Center - 300175812
Kitaadachi-gun, Japan
National Cancer Center Hospital
Chūōku, Japan
Cancer Institute Hospital of JFCR
Kōtoku, Japan
Osaka International Cancer Institute
Osaka, Japan
Amphia Ziekenhuis, Molengracht - Parent
Utrecht, Netherlands
Wojewodzkie Centrum Onkologii
Gdansk, Poland
SP ZOZ Szpital Uniwersytecki w Krakowie - Dept of Clinical Oncology and Oncology Clinic
Krakow, Poland
National Cancer Center
Goyang-si, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Kyungpook National University Chilgok Hospital
Daegu, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System - Division of Infectious Diseases
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
The Catholic University of Korea, Seoul St. Maryâ
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Hospital Universitario Reina Sofia - Dept of Oncology
Córdoba, Spain
Hospital Universitari Vall d'Hebron - Oncology Dept.
Barcelona, Spain
Hospital Clinic de Barcelona - Servicio de Oncologia
Barcelona, Spain
Hospital Universitario Ramon y Cajal - Servicio de Oncologia
Madrid, Spain
Hospital Universitario Nuestra Señora de Valme
Seville, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
China Medical University Hospital
Taichung, Taiwan
National Cheng Kung University Hospital - Internal Medicine
Tainan, Taiwan
Chi Mei Hospital, Liouying
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Aberdeen Royal Infirmary - Dept of Oncology
Aberdeen, United Kingdom
The Christie Hospital - Dept of Oncology
Manchester, United Kingdom
Sarah Cannon Research Institute UK
London, United Kingdom
Trial contact
US Medical Information
Communication Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/26/2026.
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