RecruitingPhase IIIEN originalColorectal cancerMetastatic / advanced

A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This study aims to address the unmet medical need of participants with metastatic colorectal cancer (mCRC) who have previously been treated with irinotecan, oxaliplatin, a fluoropyrimidine, and bevacizumab, by demonstrating an overall survival prolongation with precemtabart tocentecan (Precem-TcT) as single agent or Precem-TcT in combination with bevacizumab compared to trifluoride/tipiracil (FTD-TPI) plus bevacizumab.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzona diagnoza zaawansowanego raka jelita grubego
  • Pacjent wcześniej otrzymywał określone leki (irinotekan, oksaliplatynę, fluoropirymidinę) i choroba się pogorszyła lub nie tolerował leczenia
  • Maksymalnie 2 poprzednie linie leczenia w przypadku zaawansowanego nowotworu
  • Dobry ogólny stan zdrowia (skala ECOG 0 lub 1)
  • Zdolność połykania tabletek doustnych

✗ Disqualifies

  • Niepowstrzymane efekty uboczne z wcześniejszych terapii
  • Historia innego nowotworu w ciągu ostatnich 3 lat
  • Przerzuty do mózgu
  • Perforacja lub przesączenie przewodu pokarmowego w ciągu ostatnich 6 miesięcy
  • Niedrożność jelit, niezowiniętość jelit lub zapalenie jelit (wrzodziejące zapalenie jelita grubego, choroba Crohna)

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 24, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (21)

Rocky Mountain Cancer Centers, LLP- Aurora

Lone Tree, United States

Illinois Cancer Specialists

Arlington Heights, United States

Illinois CancerCare PC

Peoria, United States

Springfield Clinic

Springfield, United States

Profound Research LLC at Cancer and Leukemia Center

Sterling Heights, United States

Minnesota Oncology Hematology, P.A.

Saint Louis Park, United States

Missouri Cancer Associates - 150518964

Columbia, United States

SCRI Oncology Partners

Nashville, United States

Texas Oncology, P.A. - Abilene - 300210366

Abilene, United States

Texas Oncology-South Austin

Austin, United States

Texas Oncology DFW

Bedford, United States

Texas Oncology- San Antonio

San Antonio, United States

Texas Oncology, P.A. - Tyler

Tyler, United States

Virginia Oncology Associates

Newport News, United States

Blue Ridge Cancer Care - 300202915

Roanoke, United States

GenesisCare North Shore (Oncology)

St Leonards, Australia

Icon Cancer Centre Chermside

Chermside, Australia

University Health Network - Princess Margaret Cancer Centre

Toronto, Canada

National Cancer Center Hospital

Chūōku, Japan

Samsung Medical Center

Seoul, South Korea

China Medical University Hospital

Taichung, Taiwan

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/26/2026.

You can help another person

We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.