A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers are looking for new ways to treat locally advanced non-small cell lung cancer (NSCLC) that is unresected and has a gene mutation called KRAS G12C. Researchers want to learn if calderasib (MK-1084) can be given with durvalumab, an immunotherapy, to treat NSCLC after chemotherapy and radiation therapy. The goal of this trial is to learn if participants who receive calderasib and durvalumab live longer without the cancer growing or spreading compared to participants who receive placebo and durvalumab.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •U pacjentów z rakiem płuca (NSCLC) w zaawansowanym stadium, który nie został usunięty operacyjnie i nie rozprzestrzenił się.
- •Rak płuca musi mieć specyficzny rodzaj mutacji zwany KRAS G12C.
- •Pacjent musi mieć za sobą leczenie chemioterapią i radioterapią, które nie doprowadziło do pogorszenia choroby.
- •Próbka guza musi być dostępna do badań genetycznych.
✗ Disqualifies
- •Osoby z rakiem płuca innego typu (np. drobnokomórkowym).
- •Osoby z chorobami jelit, które utrudniają wchłanianie leków doustnych.
- •Osoby z poważnymi, niekontrolowanymi chorobami serca lub naczyń mózgowych.
- •Osoby, które miały już inne leczenie raka płuca (poza chemioterapią i radioterapią).
- •Osoby z inną postępującą chorobą nowotworową, wymagającą leczenia w ciągu ostatnich 3 lat.
- •Osoby z chorobą autoimmunologiczną wymagającą leczenia w ciągu ostatnich 2 lat.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 20, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (35)
NHO Revive Research Institute LLC ( Site 0118)
Lincoln, United States
New York Oncology Hematology P.C ( Site 9000)
Albany, United States
Clinica Adventista Belgrano ( Site 0304)
Ciudad Autonoma de Buenos Aires, Argentina
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0303)
Mar del Plata, Argentina
Hospital Britanico de Buenos Aires ( Site 0305)
Buenos Aires, Argentina
Athens Medical Center ( Site 1201)
Athens, Greece
University General Hospital of Alexandroupoli ( Site 1206)
Alexandroupoli, Greece
Leids Universitair Medisch Centrum ( Site 1503)
Leiden, Netherlands
University Medical Center Groningen ( Site 1505)
Groningen, Netherlands
National Cancer Center ( Site 2505)
Goyang-si, South Korea
Ajou University Hospital ( Site 2504)
Suwon, South Korea
Chungbuk National University Hospital ( Site 2502)
Cheongju-si, South Korea
Keimyung University Dongsan Hospital ( Site 2503)
Daegu, South Korea
Severance Hospital, Yonsei University Health System ( Site 2501)
Seoul, South Korea
Asan Medical Center ( Site 2500)
Seoul, South Korea
Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 1807)
Girona, Spain
Fundación Instituto Valenciano de Oncología ( Site 1809)
Valencia, Spain
Hospital Clinico San Carlos ( Site 1810)
Madrid, Spain
Hospital Universitario La Paz ( Site 1808)
Madrid, Spain
Hospital Universitario Virgen Macarena ( Site 1805)
Seville, Spain
National Cheng Kung University Hospital ( Site 2601)
Tainan, Taiwan
Mackay Memorial Hospital ( Site 2611)
Taipei, Taiwan
Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 2002)
Chernivtsi, Ukraine
Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 2012)
Kryvyi Rih, Ukraine
Communal Non-Commercial Enterprise "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Reg ( Site 2006)
Ivano-Frankivsk, Ukraine
Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 2013)
Kropyvnytskyi, Ukraine
Ukrainian Center of Tomotherapy ( Site 2014)
Kropyvnytskyi, Ukraine
Shalimov Institute of Surgery and Transplantation ( Site 2003)
Kyiv, Ukraine
Lviv Oncology Regional Treatment and Diagnostic Center ( Site 2009)
Lviv, Ukraine
Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 2000)
Lviv, Ukraine
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 2011)
Odesa, Ukraine
ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2001)
Rivne, Ukraine
Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 2004)
Vinnytsia, Ukraine
Volyn Regional Clinical Hospital ( Site 2010)
Lutsk, Ukraine
Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 2005)
Kyiv, Ukraine
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/8/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.