A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers are looking for new ways to treat locally advanced non-small cell lung cancer (NSCLC) that is unresected and has a gene mutation called KRAS G12C. Researchers want to learn if calderasib (MK-1084) can be given with durvalumab, an immunotherapy, to treat NSCLC after chemotherapy and radiation therapy. The goal of this trial is to learn if participants who receive calderasib and durvalumab live longer without the cancer growing or spreading compared to participants who receive placebo and durvalumab.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •U pacjentów z rakiem płuca (NSCLC) w zaawansowanym stadium, który nie został usunięty operacyjnie i nie rozprzestrzenił się.
- •Rak płuca musi mieć specyficzny rodzaj mutacji zwany KRAS G12C.
- •Pacjent musi mieć za sobą leczenie chemioterapią i radioterapią, które nie doprowadziło do pogorszenia choroby.
- •Próbka guza musi być dostępna do badań genetycznych.
✗ Disqualifies
- •Osoby z rakiem płuca innego typu (np. drobnokomórkowym).
- •Osoby z chorobami jelit, które utrudniają wchłanianie leków doustnych.
- •Osoby z poważnymi, niekontrolowanymi chorobami serca lub naczyń mózgowych.
- •Osoby, które miały już inne leczenie raka płuca (poza chemioterapią i radioterapią).
- •Osoby z inną postępującą chorobą nowotworową, wymagającą leczenia w ciągu ostatnich 3 lat.
- •Osoby z chorobą autoimmunologiczną wymagającą leczenia w ciągu ostatnich 2 lat.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (95)
Duly Healthcare ( Site 0158)
Lisle, United States
NHO Revive Research Institute LLC ( Site 0118)
Lincoln, United States
New York Oncology Hematology P.C ( Site 9000)
Albany, United States
WakeMed Raleigh Campus ( Site 0144)
Raleigh, United States
Virginia Cancer Specialists ( Site 0114)
Fairfax, United States
Instituto Alexander Fleming ( Site 0301)
Ciudad Autonoma de Buenos Aires., Argentina
Clinica Adventista Belgrano ( Site 0304)
Ciudad Autonoma de Buenos Aires, Argentina
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0303)
Mar del Plata, Argentina
Hospital Britanico de Buenos Aires ( Site 0305)
Buenos Aires, Argentina
Sanatorio Parque ( Site 0302)
Rosario, Argentina
Northern Beaches Hospital ( Site 2401)
Frenchs Forest, Australia
Princess Alexandra Hospital ( Site 2406)
Woolloongabba, Australia
Frankston Hospital ( Site 2403)
Frankston, Australia
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0406)
Fortaleza, Brazil
AFECC ASSOCIACAO FEMININA EDUCACAO COMBATE CANCER ( Site 0416)
Vitória, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0401)
Barretos, Brazil
Anhui Provincial Cancer Hospital ( Site 2209)
Hefei, China
Beijing Peking Union Medical College Hospital ( Site 2220)
Beijing, China
Zhongshan Hospital Affiliated to Xiamen University ( Site 2213)
Xiamen, China
The First Affiliated Hospital of Xiamen University. ( Site 2239)
Xiamen, China
The First Affiliated Hospital of Guangzhou Medical University ( Site 2211)
Guangzhou, China
The Second Affiliated Hospital of Guilin Medical University ( Site 2212)
Guilin, China
Guangxi Medical University Cancer Hospital ( Site 2202)
Nanning, China
Fourth Hospital of Hebei Medical University ( Site 2201)
Shijiazhuang, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology-Medical Oncology ( Site 2206)
Wuhan, China
Hubei Cancer Hospital ( Site 2203)
Wuhan, China
The Second Xiangya Hospital Of Central South University ( Site 2207)
Changsha, China
Hunan Cancer Hospital ( Site 2214)
Changsha, China
Nanjing Drum Tower Hospital ( Site 2224)
Nanjing, China
Shandong Cancer Hospital ( Site 2200)
Jinan, China
Zhongshan Hospital affiliated to Fudan University ( Site 2215)
Shanghai, China
Fudan University Shanghai Cancer Center ( Site 2216)
Shanghai, China
Shanxi Provincial Cancer Hospital ( Site 2227)
Taiyuan, China
Sichuan Cancer hospital. ( Site 2218)
Chengdu, China
Chongqing University Cancer Hospital ( Site 2236)
Chongqing, China
Xinjiang Medical University Cancer Hospital - Urumqi ( Site 2225)
Ürümqi, China
Taizhou Hospital of Zhejiang Province ( Site 2223)
Linhai, China
The First Affiliated Hospital of Wenzhou Medical University ( Site 2235)
Wenzhou, China
Clinique Teissier Groupe ( Site 1006)
Valenciennes, France
Gemeinschaftspraxis für Hämatologie und Onkologie Münster ( Site 1108)
Münster, Germany
Katholisches Marienkrankenhaus gGmbH ( Site 1101)
Hamburg, Germany
ALEXANDRA General Hospital of Athens ( Site 1200)
Athens, Greece
Athens Medical Center ( Site 1201)
Athens, Greece
Metaxa Cancer Hospital of Piraeus ( Site 1203)
Piraeus, Greece
University General Hospital of Alexandroupoli ( Site 1206)
Alexandroupoli, Greece
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 1403)
Meldola, Italy
Istituto Nazionale Tumori Regina Elena ( Site 1404)
Rome, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1401)
Rome, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1400)
Milan, Italy
Sendai Kousei Hospital ( Site 2300)
Sendai, Japan
Radboudumc ( Site 1504)
Nijmegen, Netherlands
Leids Universitair Medisch Centrum ( Site 1503)
Leiden, Netherlands
University Medical Center Groningen ( Site 1505)
Groningen, Netherlands
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1602)
Przemyśl, Poland
National Cancer Center ( Site 2505)
Goyang-si, South Korea
Ajou University Hospital ( Site 2504)
Suwon, South Korea
Chungbuk National University Hospital ( Site 2502)
Cheongju-si, South Korea
Keimyung University Dongsan Hospital ( Site 2503)
Daegu, South Korea
Severance Hospital, Yonsei University Health System ( Site 2501)
Seoul, South Korea
Asan Medical Center ( Site 2500)
Seoul, South Korea
Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 1807)
Girona, Spain
Fundación Instituto Valenciano de Oncología ( Site 1809)
Valencia, Spain
Hospital Universitari Vall d'Hebron ( Site 1800)
Barcelona, Spain
HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1803)
Madrid, Spain
Hospital Clinico San Carlos ( Site 1810)
Madrid, Spain
Hospital Universitario La Paz ( Site 1808)
Madrid, Spain
Hospital Universitario Virgen Macarena ( Site 1805)
Seville, Spain
Taipei Medical University Shuang Ho Hospital ( Site 2612)
New Taipei City, Taiwan
National Cheng Kung University Hospital ( Site 2601)
Tainan, Taiwan
Mackay Memorial Hospital ( Site 2611)
Taipei, Taiwan
National Taiwan University Cancer Center (NTUCC) ( Site 2610)
Taipei, Taiwan
Tri-Service General Hospital ( Site 2608)
Taipei, Taiwan
Ankara Bilkent Şehir Hastanesi. ( Site 1906)
Çankaya, Turkey (Türkiye)
KARTAL DR. LÜTF KIRDAR ETM VE ARATIRMA HASTANES. ( Site 1909)
Kartal, Turkey (Türkiye)
Adana Medical Park Seyhan Hastanesi ( Site 1910)
Adana, Turkey (Türkiye)
Hacettepe Universite Hastaneleri ( Site 1900)
Ankara, Turkey (Türkiye)
Liv Hospital Ankara ( Site 1911)
Ankara, Turkey (Türkiye)
Erciyes University ( Site 1904)
Kayseri, Turkey (Türkiye)
Mersin Sehir Eğitim ve Araştırma Hastanesi. ( Site 1907)
Mersin, Turkey (Türkiye)
Recep Tayyip Erdogan University Training and Research Hospital ( Site 1908)
Rize, Turkey (Türkiye)
Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 2002)
Chernivtsi, Ukraine
Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 2012)
Kryvyi Rih, Ukraine
Communal Non-Commercial Enterprise "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Reg ( Site 2006)
Ivano-Frankivsk, Ukraine
Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 2013)
Kropyvnytskyi, Ukraine
Ukrainian Center of Tomotherapy ( Site 2014)
Kropyvnytskyi, Ukraine
Kyiv City Clinical Oncology Center ( Site 2015)
Kyiv, Ukraine
Lviv Oncology Regional Treatment and Diagnostic Center ( Site 2009)
Lviv, Ukraine
Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 2000)
Lviv, Ukraine
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 2011)
Odesa, Ukraine
ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2001)
Rivne, Ukraine
Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 2004)
Vinnytsia, Ukraine
Volyn Regional Clinical Hospital ( Site 2010)
Lutsk, Ukraine
Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 2005)
Kyiv, Ukraine
Shalimov Institute of Surgery and Transplantation ( Site 2003)
Kyiv, Ukraine
St James's University Hospital ( Site 2100)
Leeds, United Kingdom
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/8/2026.
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