Multimodal Prehabilitation and Rehabilitation for Men Undergoing Robot-Assisted Radical Prostatectomy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Prostate cancer is the most common cancer in Australian men. Robot-assisted radical prostatectomy (RARP) - surgical removal of the prostate - is a standard treatment, but it frequently causes erectile dysfunction (ED) and urinary incontinence that can persist for years and significantly affect quality of life. This trial (ROBOPREP) will test whether a multimodal program of prehabilitation (before surgery) and rehabilitation (after surgery) improves erectile function and urinary continence in men undergoing RARP, compared to standard care alone. The program includes four components, all delivered virtually and in a self-directed manner: 1. Pharmacological - tadalafil 5 mg once daily (a low-dose, TGA-approved erectile medication) beginning 4 weeks before surgery, paused during hospital admission, and resumed for 3 months following catheter removal after surgery. 2. Exercise - pelvic floor muscle training (3 sets per day) and aerobic exercise (40 minutes, 4 times per week) to strengthen the muscles and vascular supply involved in erectile and urinary function. 3. Nutrition - dietary guidance to support surgical recovery and vascular health. 4. Psychological/wellbeing - relaxation techniques, psychoeducation about expected recovery, and self-compassion strategies to address cancer-related anxiety. A total of 64 men will be recruited across three major Sydney hospitals (Royal Prince Alfred Hospital, Concord Repatriation General Hospital, and Chris O'Brien Lifehouse) and randomly assigned 1:1 to the multimodal program plus standard care, or to standard care alone. Outcomes - including erectile function (primary), urinary continence, quality of life, and psychological wellbeing - are assessed at baseline and at 6 weeks, 3, 6, and 12 months following surgery. All participant-facing elements of the program are digital, low-cost, and designed for real-world scalability.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Zaplanowana operacja usunięcia gruczołu krokowego z powodu raka prostaty
- •Wizyta u urologa w szpitalu uczestniczącym minimum 4 tygodnie przed operacją
- •Chęć do samodzielnego wykonywania ćwiczeń i zaleceń przez internet
- •Zachowanie nerwów przy gruczole krokowym (pełne po jednej stronie lub ponad 50% po obu stronach)
✗ Disqualifies
- •Poważne problemy z rozumieniem lub wyrażaniem zgody na uczestnictwo
- •Stosowanie zastrzyków do członka moczowego
- •Całkowita niesprawność seksualna przed operacją
- •Przyjmowanie leków rozszerzających naczynia krwionośne (nitratów)
- •Poważne problemy z nerkami lub wątrobą
- •Zawał serca w ciągu ostatnich 90 dni lub udar w ciągu ostatnich 6 miesięcy
- •Niestabilna choroba serca lub problemy z rytmem serca
- •Brak dostępu do internetu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 9, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (3)
Chris O'Brien Lifehouse
Sydney, Australia
Royal Prince Alfred Hospital
Sydney, Australia
Concord Repatriation General Hospital (CRGH)
Sydney, Australia
Trial contact
Nicholas Hirst
SOuRCe Admin
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/10/2026.
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