BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase Ib/II trial tests the safety and side effects of BMS-986504 in combination with pemetrexed and how well the combination works in treating patients with solid tumors with MTAP deletion and that has spread from where it first started (primary site) to other places in the body (metastatic). The MTAP gene helps cells recycle important parts needed to make deoxyribonucleic acid (DNA), which is needed for cell growth and function. MTAP deletion means that the MTAP gene is missing. BMS-986504, a PRMT5 inhibitor, may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by stopping cells from using folic acid to make DNA and may kill tumor cells. Giving BMS-986504 in combination with pemetrexed may be safe, tolerable, and/or effective in treating patients with metastatic solid tumors with MTAP deletion.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowotwór złośliwy z przerzutami (rozprzestrzeniłem się na inne części ciała) i brakującym genem MTAP - raki: trzustki, dróg żółciowych, przełyku, jelita grubego lub inne zaawansowane nowotwory
- •Choroba, która pogorszyła się lub nie reaguje na poprzednie standardowe leczenie
- •Co najmniej jeden widoczny guz, który można zmierzyć
- •Wiek 18 lat lub więcej
- •Dobra ogólna kondycja zdrowotna (stopień 0-1 w skali ECOG)
- •Wystarczająca liczba białych krwinek (ANC ≥ 1500/mcL)
- •Otrzymanie pemetreksydu w przeszłości jest dopuszczalne, z wyjątkiem raka płuca
- •Przerwa co najmniej 3 tygodnie od poprzedniej chemioterapii lub radioterapii
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 25, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Northwestern University
Chicago, United States
Trial contact
Study Coordinator
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/26/2026.
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