Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests how well giving botensilimab and balstilimab prior or to surgery (neoadjuvent) works for the treatment of colorectal cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and that can be removed by surgery (resectable) colorectal cancer. Immunotherapy with monoclonal antibodies, such as botensilimab and balstilimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving botensilimab and balstilimab before surgery may make the tumor smaller. Giving neoadjuvant botensilimab and balstilimab may be effective for the treatment of advanced resectable colorectal cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wyrażenie świadomej zgody na udział w badaniu.
- •Wiek co najmniej 18 lat.
- •Rak jelita grubego potwierdzony badaniami.
- •Choroba w stadium, które pozwala na operacyjne usunięcie.
- •Stan ogólny pacjenta pozwalający na udział w badaniu (wg skali ECOG do 2).
- •Liczba pewnych białych krwinek (neutrofile) co najmniej 1500 w mm sześciennym.
- •Płytki krwi co najmniej 75 000 w mm sześciennym.
- •Hemoglobina co najmniej 8.
✗ Disqualifies
- •Rak odbytnicy wymagający radioterapii przed operacją.
- •Choroba nowotworowa niezaawansowana (stadium IIA z N0).
- •Choroba rozsiana (stadium IV).
- •Tłumaczenie transfuzji płytek krwi w ciągu 14 dni przed ich badaniem.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (11)
CTCA at Western Regional Medical Center
Goodyear, United States
City of Hope Corona
Corona, United States
City of Hope Medical Center
Duarte, United States
City of Hope Seacliff
Huntington Beach, United States
City of Hope at Irvine Lennar
Irvine, United States
City of Hope at Long Beach Elm
Long Beach, United States
City of Hope South Pasadena
South Pasadena, United States
City of Hope Upland
Upland, United States
City of Hope Atlanta Cancer Center
Newnan, United States
City of Hope at Illinois Chicago Downtown
Chicago, United States
City of Hope at Chicago
Zion, United States
Trial contact
Sebastian Perez
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.