MONTEROSA - Italian Multicenter Observational Study to Evaluate Time to Clinical Hepatic Decompensation, Quality of Life, Effectiveness, and Safety of Tremelimumab Plus Durvalumab in Patients With Advanced or Unresectable Hepatocellular Carcinoma Who Have Received no Prior Systemic Treatment.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Italian multicenter observational study to evaluate time to clinical hepatic decompensation, quality of life, effectiveness, and safety of tremelimumab plus durvalumab in patients with advanced or unresectable hepatocellular carcinoma who have received no prior systemic treatment.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek powyżej 18 lat
- •Potwierdzony rozpoznaniem zaawansowany lub nieresekcyjny rak wątroby
- •Zdiagnozowany jako BCLC B lub C
- •Prawidłowa funkcja wątroby (Child-Pugh A)
- •Dobry stan ogólny pacjenta (ECOG 0 lub 1)
- •Planowane leczenie pierwszej linii nowymi lekami immunologicznymi (STRIDE)
✗ Disqualifies
- •Wcześniejsze leczenie systemowe raka wątroby
- •Poprzednia terapia immunologiczna
- •Historia przeszczepienia narządu lub szpiku
- •Krwawienia z przewodu pokarmowego w ostatnim roku
- •Zakrzepica głównego pnia żyły wrotnej
- •Choroby autoimmunologiczne wymagające leczenia immunosupresyjnego
- •Uczulenie na składniki leku STRIDE
- •Ciąża lub karmienie piersią
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 100 Years
- Last updated (source)
- July 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (24)
Research site
Ancona, Italy
Research Site
Ancona, Italy
Research Site
Bergamo, Italy
Research site
Foggia, Italy
Research Site
Foggia, Italy
Research Site
Meldola, Italy
Research site
Milan, Italy
Research Site
Milan, Italy
Research site
Modena, Italy
Research Site
Modena, Italy
Research site
Naples, Italy
Research Site
Naples, Italy
Research Site
Padova, Italy
Research Site
Palermo, Italy
Research Site
Pisa, Italy
Research site
Pozzuoli, Italy
Research Site
Pozzuoli, Italy
Research Site
Roma, Italy
Research site
Rozzano, Italy
Research Site
Rozzano, Italy
Research site
Torino, Italy
Research Site
Torino, Italy
Research site
Verona, Italy
Research Site
Verona, Italy
Trial contact
AstraZeneca Clinical Study Information Center AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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