Prognostic and Predictive Role of Intrinsic Molecular Subtypes in BRCA-associated Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is an observational study being carried out in several hospitals. No extra tests or procedures are required beyond those already part of normal medical care. The study is sponsored by the University of Modena and Reggio Emilia and aims to include about 100 patients. The main goal of the study is to better understand the different biological types of breast cancer in patients who have hormone receptor-positive (HR-positive), HER2-negative breast cancer related to BRCA gene mutations. In particular, the study will explore whether these cancers tend to belong to molecular types that may respond less to endocrine or CDK4/6 inhibitor therapy. The study also compares cancers linked to BRCA1 and BRCA2 mutations and investigates whether the different biological types are associated with differences in disease outcomes and response to treatment.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Diagnoza raka piersi potwierdzony w badaniu histologicznym, który reaguje na hormony (HR+) i nie reaguje na HER2 (HER2-), oraz posiadanie mutacji genu BRCA1 lub BRCA2
- •Dostęp do dokumentacji medycznej ze szpitala lub poradni
- •Dostępna próbka tkanki raka piersi zachowana w specjalny sposób (z miejsca guza pierwotnego lub przerzutu)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 1, 2026
- Sex
- No restrictions
Locations (6)
Ospedale San Martino di Genova
Genova, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori Milano
Milan, Italy
Istituto Oncologico Europeo di Milano
Milan, Italy
Azienda Ospedaliero-Universitaria Policlinico di Modena
Modena, Italy
Istituto Oncologico Veneto IRCCS Padova
Padova, Italy
Fondazione Policlinico Universitario Agostino Gemelli di Roma
Roma, Italy
Trial contact
Matteo Lambertini, MD
Claudio Vernieri, MD
Antonio Marra, MD
Angela Toss, MD
Gaia Griguolo, MD
Antonella Palazzo, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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