A Study of Tepotinib and Ivonescimab in People With Non-Small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The researchers are doing this study to find out whether the combination of tepotinib and ivonescimab is a safe and effective treatment for people with non-small cell lung cancer (NSCLC) that is positive for METex14 skipping. The researchers will test up to two different doses of tepotinib in combination with ivonescimab to find the best dose of tepotinib that causes few or mild side effects in participants.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak płuca bez drobnych komórek (każdy typ)
- •Mutacja METex14 w komórkach nowotworu potwierdzona w certyfikowanym laboratorium
- •Zaawansowana lub nawracająca choroba (stadium IV lub stadium IIIB/C bez możliwości operacji/radioterapii)
- •Mierzone ogniska choroby widoczne w badaniach obrazowych
- •Pacjenci mogą mieć poprzednie leczenie inhibitorami MET lub immunoterapią
- •Jeśli był udar mózgu, musi być wyleczony i bezobjawowy przez co najmniej 3-14 dni
✗ Disqualifies
- •Inne mutacje nowotworów, takie jak EGFR, ALK, ROS1, RET, HER2, KRAS czy BRAF
- •Przerzuty do opon mózgowych lub do mózgu (chyba że były leczone i są bezobjawowe)
- •Wcześniejsze leczenie lekami blokującymi nowe naczynia krwionośne (bevacizumab, ramucirumab)
- •Inne leczenie systemowe w ciągu 21 dni przed rozpoczęciem badania
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (7)
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, United States
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, United States
Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities )
Commack, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, United States
Memorial Sloan Kettering Nassau (All Protocol Activities)
Uniondale, United States
Trial contact
Paul Paik, MD
Helena Yu, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/17/2026.
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