A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I trial studies the safety and side effects of a new positron emission tomography (PET) imaging agent called 64Cu-DOTA-pembrolizumab to see how well it works in determining treatment response for patients with stage IV non-small cell lung cancer (NSCLC) already receiving pembrolizumab. 64Cu-DOTA-pembrolizumab consists of a monoclonal antibody, pembrolizumab, that binds to a protein called PD-1 that is expressed on tumor cells. PET scans can then visualize the tumor cells using 64Cu, a radioactive substance. 64Cu-DOTA-pembrolizumab PET scans may be safe and useful to doctors in telling the difference between tumors that are still growing and areas that are not growing in patients with stage IV NSCLC receiving pembrolizumab treatment.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony zaawansowany rak płuc (stadium IV)
- •Pacjent obecnie leczony pembrolizumabem
- •Kwalifikacja do radioterapii stereotaktycznej
- •Liczba neutrofili w normie (≥1000/mm³)
- •Liczba płytek krwi wystarczająca (≥50000/mm³)
- •Funkcja nerek w normie (oczyszczanie kreatyniny ≥30 mL/min)
- •Dla kobiet w wieku rozrodczym: negatywny test ciąży
✗ Disqualifies
- •Plan przerwania leczenia pembrolizumabem w momencie rozpoczęcia badania
- •Szczepienie żywymi szczepionkami w ciągu 4 tygodni przed badaniem (z wyjątkiem szczepionek na COVID-19 i grypę)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 12, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
City of Hope Medical Center
Duarte, United States
Trial contact
Sagus Sampath
Sagus Sampath
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/13/2026.
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