A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
A first in human study to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of BLU-924 / SAR449336, a pan-KRAS inhibitor, in participants with advanced Pancreatic Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer harboring KRAS mutations.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony diagnozą zaawansowany rak trzustki, płuc lub jelita grubego z mutacją KRAS (G12C, G12D, G12V, G12A, G12S lub G13D)
- •Możliwość zmierzenia wielkości guza
- •Ogólny stan zdrowia pozwalający na uczestnictwo w badaniu
- •Wcześniejsze leczenie standardowymi metodami dla Twojego rodzaju raka lub medycznie uzasadnionych powodów uniemożliwiających takie leczenie
✗ Disqualifies
- •Inny nowotwór zdiagnozowany w ciągu ostatnich 2 lat
- •Aktywne przerzuty do mózgu (z pewnymi wyjątkami)
- •Poprzednie leczenie ukierunkowane na gen KRAS
- •Aktywna lub niekontrolowana infekcja, w tym gruźlica, hepatitis B, hepatitis C lub HIV
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 21, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (16)
Florida Cancer Specialists & Research Institute - Sarasota
Sarasota, United States
Moffitt Cancer Center
Tampa, United States
Mary Bird Perkins Cancer Center
Baton Rouge, United States
Massachusetts General Hospital - Main Campus
Boston, United States
University of Michigan Medical School Rogel Cancer Center
Ann Arbor, United States
Hackensack University Medical Center
Hackensack, United States
NYU Langone Health Perlmutter Cancer Center
New York, United States
Tennessee Oncology, PLLC
Nashville, United States
The University of Texas MD Anderson Cancer Center - Texas Medical Center
Houston, United States
Next Oncology Virginia Cancer Specialist
Fairfax, United States
Mi Cancer Center Barcelona (Pratia Sirius Barcelona)
Barcelona, Spain
Hospital Universitario Vall d'Hebron
Barcelona, Spain
Hospital General Universitrio Gregorio Maranon
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
NEXT Oncology - Madrid
Pozuelo de Alarcón, Spain
Clinica Universidad de Navarra (CUN)
Pamplona, Spain
Trial contact
Blueprint Medicines
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/11/2026.
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