Effects of Infusion Timing on Treatment Response in Solid Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study evaluates whether the time of day when immunotherapy is given affects clinical outcomes. It includes patients eligible for PD-1 (programmed cell death protein 1) or PD-L1 (programmed death-ligand 1) inhibitor treatment who have either advanced or metastatic non-small cell lung cancer (NSCLC) or locally advanced, resectable head and neck squamous cell carcinoma (HNSCC).The study tests the hypothesis that outcomes differ based on infusion timing (morning versus afternoon). Patients are divided into two cohorts by disease type: Cohort 1 includes NSCLC and Cohort 2 includes HNSCC. Within each cohort, patients are randomly assigned to receive infusions in the morning or afternoon, using a 2:1 ratio for NSCLC and a 1:1 ratio for HNSCC. All treatment and disease assessments follow standard medical care, and outcomes such as survival and treatment response are collected from medical records. Patients will be followed for up to 2 years.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznanie zaawansowanego raka płuca bez drobnych komórek (NSCLC) lub raka głowy i szyi
- •Wiek co najmniej 18 lat
- •Wyrażenie pisemnej zgody na udział w badaniu
- •Zdolność i chęć do uczestniczenia w procedurach badania
✗ Disqualifies
- •Przyjmowanie sterydów (kortyzonu) w wysokiej dawce, których nie można odstawić 7 dni przed leczeniem
- •Poprzednie leczenie podobnymi lekami immunologicznymi w ciągu ostatnich 6 miesięcy
- •Jednoczesny udział w innym badaniu klinicznym z nowym lekiem
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
University of North Carolina at Chapel Hill, Department of Radiation Oncology
Chapel Hill, United States
Trial contact
Adrianna Warner
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/16/2026.
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