Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to evaluate izalontamab brengitecan (iza-bren) combined with osimertinib in participants with previously untreated, locally advanced or metastatic EGFR-mutant NSCLC, compared to osimertinib alone or osimertinib combined with platinum-based chemotherapy
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowotwór płuca (nieepermukomorowy) w stadium zaawansowanym lub przerzutowym, który nie można wyleczyć chirurgią lub radioterapią
- •Posiadanie określonej mutacji genu EGFR (delecja egzonu 19 lub mutacja L858R w egzonie 21)
- •Mierzalne ogniska choroby poza mózgiem
- •Ogólny stan zdrowia oceniony na 0-1 (pacjent może wykonywać zwykłe czynności)
✗ Disqualifies
- •Przerzuty do mózgu, opon mózgowych lub uszkodzenie rdzenia kręgowego powodujące objawy, które nie są kontrolowane
- •Historia zapalenia płuc wymagająca leczenia sterydami lub obecne podejrzenie zapalenia płuc
- •Poważna choroba serca
- •Wcześniejsze leczenie inhibitorami kinazy tyrozynowej (TKI) dla tego nowotworu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 8, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (201)
Local Institution - 0212
Beverly Hills, United States
Local Institution - 0504
Fullerton, United States
Local Institution - 0357
La Jolla, United States
Local Institution - 0520
Boulder, United States
Local Institution - 0527
Fort Myers, United States
Local Institution - 0366
Orlando, United States
Cancer Care Centers of Brevard - Rockledge
Palm Bay, United States
Local Institution - 0526
St. Petersburg, United States
Local Institution - 0524
West Palm Beach, United States
Local Institution - 0207
Ottawa, United States
Local Institution - 0503
Baltimore, United States
Local Institution - 0523
Silver Spring, United States
Local Institution - 0521
Edina, United States
Local Institution - 0364
Saint Paul, United States
Local Institution - 0403
St Louis, United States
Local Institution - 0402
Omaha, United States
Local Institution - 0290
Lebanon, United States
Local Institution - 0183
New Brunswick, United States
Local Institution - 0153
New York, United States
Local Institution - 0157
The Bronx, United States
Local Institution - 0385
Charlotte, United States
Local Institution - 0438
Sandusky, United States
Local Institution - 0404
Portland, United States
Local Institution - 0487
Easton, United States
Local Institution - 0200
Sioux Falls, United States
Local Institution - 0199
Memphis, United States
Texas Oncology
Beaumont, United States
Local Institution - 0525
Dallas, United States
Texas Oncology - San Antonio
San Antonio, United States
Local Institution - 0411
Salt Lake City, United States
Local Institution - 0165
Fairfax, United States
Local Institution - 0530
Fairfax, United States
Shenandoah Oncology, P.C. (Shenandoah Oncology Associates, P.C.)
Winchester, United States
Local Institution - 0283
Seattle, United States
Local Institution - 0502
Morgantown, United States
Local Institution - 0077
Mar del Plata, Argentina
Local Institution - 0514
Río Cuarto, Argentina
Local Institution - 0086
Buenos Aires, Argentina
Local Institution - 0432
Buenos Aires, Argentina
Local Institution - 0085
Buenos Aires, Argentina
Local Institution - 0078
Buenos Aires, Argentina
Local Institution - 0151
Buenos Aires, Argentina
Local Institution - 0424
Camperdown, Australia
Local Institution - 0439
Westmead, Australia
Local Institution - 0511
Greenslopes, Australia
Local Institution - 0492
Adelaide, Australia
Local Institution - 0447
Clayton, Australia
Local Institution - 0437
Murdoch, Australia
Local Institution - 0253
Vitória, Brazil
Local Institution - 0291
Salvador, Brazil
Local Institution - 0247
Ijuí, Brazil
Local Institution - 0252
Florianópolis, Brazil
Local Institution - 0244
Barretos, Brazil
Local Institution - 0249
Campinas, Brazil
Local Institution - 0261
Sorocaba, Brazil
Local Institution - 0255
Rio de Janeiro, Brazil
Local Institution - 0259
São Paulo, Brazil
Local Institution - 0059
Edmonton, Canada
Local Institution - 0056
Vancouver, Canada
Local Institution - 0058
Montreal, Canada
Local Institution - 0057
Montreal, Canada
Local Institution - 0040
Regina, Canada
Local Institution - 0517
Beijing, China
Local Institution - 0458
Beijing, China
Local Institution - 0535
Chongqing, China
Local Institution - 0470
Chongqing, China
Local Institution - 0493
Fuzhou, China
Local Institution - 0457
Fuzhou, China
Local Institution - 0326
Dongguan Shi, China
Local Institution - 0331
Guangzhou, China
Local Institution - 0512
Jiangmen, China
Local Institution - 0478
Zhongshan, China
Local Institution - 0321
Guilin, China
Local Institution - 0328
Nanning, China
Local Institution - 0505
Guiyang, China
Local Institution - 0330
Haikou, China
Local Institution - 0322
Shijiazhuang, China
Local Institution - 0343
Harbin, China
Local Institution - 0298
Anyang, China
Local Institution - 0341
Weihui Shi, China
Local Institution - 0480
Zhengzhou, China
Local Institution - 0423
Zhengzhou, China
Local Institution - 0483
Jingzhou, China
Local Institution - 0450
Wuhan, China
Local Institution - 0482
Changsha, China
Local Institution - 0467
Changsha, China
Local Institution - 0306
Changsha Shi, China
Local Institution - 0531
Lianyungang, China
Local Institution - 0347
Nanjing, China
Local Institution - 0332
Shenyang, China
Local Institution - 0464
Xi'an, China
Local Institution - 0479
Binzhou, China
Local Institution - 0455
Jinan, China
Local Institution - 0413
Linyi, China
Local Institution - 0469
Weifang Shi, China
Local Institution - 0319
Shanghai Shi, China
Local Institution - 0316
Taiyuan, China
Local Institution - 0463
Taiyuan, China
Local Institution - 0456
Chengdu, China
Local Institution - 0471
Chengdu, China
Local Institution - 0534
Chengdu, China
Local Institution - 0320
Dazhou Shi, China
Local Institution - 0472
Yibin, China
Local Institution - 0452
Tianjin, China
Local Institution - 0312
Hangzhou, China
Local Institution - 0074
Marseille, France
Local Institution - 0063
Dijon, France
Local Institution - 0075
Nantes, France
Local Institution - 0064
La Tronche, France
Local Institution - 0116
Lyon, France
Local Institution - 0109
Paris, France
Local Institution - 0062
Bron, France
Local Institution - 0069
Villejuif, France
Local Institution - 0073
Brest, France
Local Institution - 0066
Caen, France
Local Institution - 0070
Toulouse, France
Local Institution - 0071
Paris, France
Local Institution - 0112
Gerlingen, Germany
Local Institution - 0001
Munich, Germany
Local Institution - 0105
Regensburg, Germany
Local Institution - 0446
Frankfurt am Main, Germany
Local Institution - 0106
Oldenburg, Germany
Local Institution - 0100
Cologne, Germany
Local Institution - 0243
Dortmund, Germany
Local Institution - 0104
Essen, Germany
Local Institution - 0117
Hemer, Germany
Local Institution - 0101
Münster, Germany
Local Institution - 0103
Dresden, Germany
Local Institution - 0412
Leipzig, Germany
Local Institution - 0108
Großhansdorf, Germany
Local Institution - 0239
Lübeck, Germany
Local Institution - 0445
Giessen, Germany
Local Institution - 0225
Vadodara, India
Local Institution - 0444
Badsa, India
Local Institution - 0337
Gurgaon, India
Local Institution - 0436
Belagavi, India
Local Institution - 0215
Pune, India
Local Institution - 0233
Mohali, India
Local Institution - 0222
Chennai, India
Local Institution - 0236
Meldola, Italy
Local Institution - 0094
Candiolo, Italy
Local Institution - 0093
Bergamo, Italy
Local Institution - 0289
Brescia, Italy
Local Institution - 0089
Milan, Italy
Local Institution - 0087
Milan, Italy
Local Institution - 0238
Milan, Italy
Local Institution - 0091
Pavia, Italy
Local Institution - 0088
Verona, Italy
Local Institution - 0262
Nagoya, Japan
Local Institution - 0128
Toon-Shi, Japan
Local Institution - 0136
Kurume-Shi, Japan
Local Institution - 0121
Yokohama, Japan
Local Institution - 0122
Sendai, Japan
Local Institution - 0433
Okayama, Japan
Local Institution - 0125
Hirakata-Shi, Japan
Local Institution - 0129
Osakasayama-Shi, Japan
Local Institution - 0141
Hamamatsu, Japan
Local Institution - 0137
Chūōku, Japan
Local Institution - 0414
Kōtoku, Japan
Local Institution - 0140
Cheongju-si, South Korea
Local Institution - 0138
Buk-Gu, South Korea
Local Institution - 0506
Dalseo, South Korea
Local Institution - 0127
Goyang-si, South Korea
Local Institution - 0133
Seongnam-si, South Korea
Local Institution - 0134
Hwasun-Gun, South Korea
Local Institution - 0124
Seocho -Gu, South Korea
Local Institution - 0123
Songpa-Gu, South Korea
Local Institution - 0131
Seoul, South Korea
Local Institution - 0139
Gyeongsangnam-do, South Korea
Local Institution - 0135
Seoul, South Korea
Local Institution - 0126
Seoul, South Korea
Local Institution - 0143
Majadahonda, Spain
Local Institution - 0147
Seville, Spain
Local Institution - 0242
A Coruña, Spain
Local Institution - 0144
Jaén, Spain
Local Institution - 0226
Jaén, Spain
Local Institution - 0149
Jerez de la Frontera, Spain
Local Institution - 0148
Madrid, Spain
Local Institution - 0150
Málaga, Spain
Local Institution - 0241
Valencia, Spain
Local Institution - 0229
Kaohsiung City, Taiwan
Local Institution - 0230
New Taipei City, Taiwan
Local Institution - 0223
Taipei City, Taiwan
Local Institution - 0227
Gaoxiongka, Taiwan
Local Institution - 0221
Taoyuan City, Taiwan
Local Institution - 0418
Taichung, Taiwan
China Medical University Hospital
Taichung, Taiwan
Local Institution - 0420
Tainan, Taiwan
Local Institution - 0275
Bangkok, Thailand
Local Institution - 0263
Din Daeng, Thailand
Local Institution - 0021
Sur, Turkey (Türkiye)
Local Institution - 0265
Pendik, Turkey (Türkiye)
Local Institution - 0014
Adana, Turkey (Türkiye)
Local Institution - 0019
Adana, Turkey (Türkiye)
Local Institution - 0008
Ankara, Turkey (Türkiye)
Local Institution - 0003
Ankara, Turkey (Türkiye)
Local Institution - 0015
Antalya, Turkey (Türkiye)
Local Institution - 0041
Istanbul, Turkey (Türkiye)
Local Institution - 0039
Istanbul, Turkey (Türkiye)
Local Institution - 0050
Izmir, Turkey (Türkiye)
Local Institution - 0037
Izmir, Turkey (Türkiye)
Trial contact
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
First line of the email MUST contain NCT # and Site #.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/9/2026.
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