MRI-DTI Assessment of Urethral Internal Sphincter Ring and Prostate Base Morphology
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a single-center, observational imaging study designed to evaluate the in vivo morphology of the male urethral internal sphincter ring using magnetic resonance diffusion tensor imaging (MRI-DTI) fiber tracking and to investigate its relationship with prostate base morphology. Male participants undergoing clinically indicated pelvic, seminal vesicle, or prostate-related MRI-DTI examinations will be included. The study population may include patients with benign prostatic enlargement, younger men undergoing MRI for suspected cryptorchidism or suspected seminal vesiculitis, and patients with prostate cancer scheduled to receive androgen deprivation therapy (ADT). All participants will undergo T2-weighted imaging and DTI. T2WI-DTI image registration, dual-region-of-interest fiber tracking, and three-dimensional reconstruction will be used to visualize ring-like muscle fiber structures in the bladder neck, prostate base, and proximal urethral region. The cross-sectional imaging cohort will be used to assess the associations between prostate-side morphological parameters, including prostate volume, prostate base diameter or area, and intravesical prostatic protrusion, and sphincter-ring parameters, including ring inner diameter and ring area. The ADT paired cohort will undergo MRI-DTI before treatment and during follow-up after ADT to evaluate whether reduction in prostate volume and prostate base morphology is accompanied by corresponding changes in the urethral internal sphincter ring. This study will not alter the participants' existing clinical diagnostic or treatment pathways. Imaging data will be analyzed using standardized post-processing and quantitative measurement procedures. The results may provide in vivo imaging evidence for age- and prostate-related displacement and morphological remodeling of the male urethral internal sphincter and may inform future surgical strategies for identifying, preserving, or reconstructing proximal urinary continence-related structures.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Mężczyzna, który ma wykonane badanie MRI z przyczyn medycznych dotyczących miednicy, prostaty lub pęcherzyków nasiennych
- •Posiadanie wysokiej jakości obrazów MRI pozwalających na pomiar mięśnia zwieracza cewki moczowej
- •Możliwość poddania się badaniu MRI bez problemów
- •Chętna zgoda na uczestnictwo w badaniu
✗ Disqualifies
- •Posiadanie metalowych implantów uniemożliwiających badanie MRI lub silna klaustrofobia
- •Choroby neurologiczne zaburzające funkcję pęcherza (np. uraz rdzenia kręgowego, stwardnienie rozsiane, choroba Parkinsona)
- •Wcześniejsza radioterapia miednicy
- •Wcześniejsze operacje cewki moczowej, zwieracza lub prostaty
- •Poważne problemy kardiologiczne, zaburzenia poznawcze lub psychiatryczne uniemożliwiające udział w badaniu
- •Stosowanie leków w ciągu ostatnich 3 miesięcy mogących wpływać na funkcję mięśni dolnych dróg moczowych
Simplified criteria — AI translation
Trial details
- Minimum age
- 15 Years
- Maximum age
- 90 Years
- Last updated (source)
- July 20, 2026
- Sex
- Male only
Locations (1)
JiangsuTaizhouPH
Taizhou, China
Trial contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/21/2026.
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