Perioperative HLX10 (Serplulimab) With S-1+Oxaliplatin (SOX) in Locally Advanced and PD-L1-Positive Gastric or Esophagogastric Junction Adenocarcinoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
To evaluate the clinical efficacy of perioperative treatment with S-1 + oxaliplatin (SOX)+ HLX10 compared with SOX as the control in patients with cT3-4N1-3M0 PD-L1-positive (CPS ≥ 5) locally advanced gastric adenocarcinoma or gastroesophageal junction adenocarcinoma, in a placebo-controlled, double-blind, randomized phase II investigator-initiated clinical study.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rozpoznanie raka żołądka lub złączenia przełyku ze żołądkiem
- •Guz wykazujący dodatni wynik testu PD-L1 (CPS ≥ 5)
- •Guz zaawansowany lokalnie (stadium cT3-4N1-3M0) bez wcześniejszego leczenia systemowego
- •Ocena lekarza, że można całkowicie usunąć guza chirurgicznie
- •Wiek 18-80 lat
- •Dobry ogólny stan zdrowia (ECOG 0 lub 1)
- •Prawidłowe wyniki badań krwi i testów wątroby oraz nerek
- •Kobiety mogą być w wieku rozrodczym tylko jeśli test ciążowy jest ujemny
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 80 Years
- Last updated (source)
- July 23, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (18)
Chiba Cancer Center
Chiba, Japan
Kyushu Cancer Center
Fukuoka, Japan
Gifu University Hospital
Gifu, Japan
Gunma University Hospital
Maebashi, Japan
Hiroshima University Hospital
Hiroshima, Japan
St. Marianna University Hospital
Kawasaki, Japan
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
Yokohama, Japan
Saitama Prefectural Cancer Center
Ina, Japan
Osaka International Cancer Institute
Osaka, Japan
Osaka Medical and Pharmaceutical University Hospital
Takatsuki, Japan
Saitama Medical University International Medical Center
Hidaka, Japan
Shizuoka Cancer Center
Nagaizumi-chō, Japan
National Cancer Center Hospital
Chuo Ku, Japan
Cancer Institute Hospital of JFCR
Koto-Ku, Japan
National Cancer Center Korea
Goyang-si, South Korea
Ajou University Hospital
Suwon, South Korea
Seoul St. Mary's Hospital
Seocho, South Korea
Asan Medical Center
Songpa-dong, South Korea
Trial contact
Ken Kato, M.D., Ph.D.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/24/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.