HPV-associated Oropharyngeal Carcinoma (HPV-OPC)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study focuses on the longitudinal monitoring of HPV infection in patients with head and neck cancers, particularly oropharyngeal carcinoma (OPC), using a new electrochemical detection method. This method has already been successfully developed and validated for cervical cancer. The aim of the project is to monitor the dynamics of HPV viral load before the start of treatment and during conservative radiation therapy or concurrent chemoradiation therapy. HPV will be analyzed from oral swabs, oral cavity washings, and plasma as part of a small prospective study. The results of the new method will be correlated with standard techniques, particularly qPCR. Longitudinal monitoring may contribute to the individualization and potential de-escalation of treatment in selected patients.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Diagnoza raka gardła kwalifikującego do radioterapii lub chemioradioterapii
- •Wiek 18 lat lub więcej
- •Potwierdzony histologicznie rodzaj nowotworu (rak płaskonabłonkowy) ze znanym statusem p16
- •Chęć udziału i możliwość podpisania zgody na uczestnictwo
- •Zdolność komunikacji z badaczem w języku lokalnym
✗ Disqualifies
- •Poprzednia chemioterapia przed leczeniem głównym
- •Nieznany status p16 lub nieprawidłowa diagnoza
- •Poprzednia radioterapia okolicy gardła
- •Pacjenci w fazie paliatywnej (leczenie łagodzące)
- •Ciąża lub karmienie piersią
- •Wiek poniżej 18 lat
- •Ciężkie uzależnienie od alkoholu lub narkotyków
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Masaryk Memorial Cancer Institute
Brno, Czechia
Trial contact
Martina Lojová, PhD
Martin Bartošík, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/23/2026.
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