An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Purpose: to assess efficacy and safety of Dato-DXd + rilvegostomig as adjuvant therapy versus SoC in MIUC participants with high-risk residual disease after radical resection. Study details: Duration: \~78 months (6.5 years) from FSI to last subject visit Treatment length: up to \~12 months, depending on randomized arm Visit frequency: every 3 weeks in Arms 1 and 2; every 2-4 weeks per SoC in Arm 3
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek powyżej 18 lat
- •Potwierdzony nowotwór pęcherza moczowego lub górnych dróg moczowych
- •Przebyta operacja usunięcia nowotworu 28-120 dni przed włączeniem do badania
- •Nowotwór wysokiego ryzyka nawrotu - określony stopień zaawansowania
- •Brak widocznych pozostałości nowotworu w badaniach przedbadaniem
- •Dobry stan ogólny pacjenta (ECOG 0-1)
- •Oczekiwana długość życia ponad 12 tygodni
- •Dostępna próbka tkanki guza do badań laboratoryjnych
✗ Disqualifies
- •Nowotwór zawierający komórki neuroendokrynne
- •Częściowe usunięcie pęcherza lub nerki
- •Poprzednie chemioterapii lub radioterapii po operacji
- •Ciężkie choroby przewlekłe lub historia przeszczepów
- •Historia chorób rogu rogówki oka
- •Inny nowotwór w przeszłości (z wyjątkami)
- •Niestabilne pozostałości po poprzednim leczeniu
- •Niekontrolowana infekcja wirusem zapalenia wątroby B lub C
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (160)
Research Site
Hot Springs, United States
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Little Rock, United States
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Little Rock, United States
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San Francisco, United States
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Chicago, United States
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Boston, United States
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Kansas City, United States
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Lincoln, United States
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Omaha, United States
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Albany, United States
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New York, United States
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Cleveland, United States
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Myrtle Beach, United States
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Nashville, United States
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Dallas, United States
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Falls Church, United States
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Seattle, United States
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Tacoma, United States
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Milwaukee, United States
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Auchenflower, Australia
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Ballarat, Australia
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Clayton, Australia
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Darlinghurst, Australia
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Elizabeth Vale, Australia
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South Brisbane, Australia
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St Albans, Australia
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Barretos, Brazil
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Curitiba, Brazil
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Salvador, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Calgary, Canada
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Abbotsford British Columbia, Canada
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Barrie, Canada
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Hamilton, Canada
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Kingston, Canada
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London, Canada
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Mississauga, Canada
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Montreal, Canada
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Montreal, Canada
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Beijing, China
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Beijing, China
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Beijing, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Chongqing, China
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Fuzhou, China
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Guangzhou, China
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Guangzhou, China
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Guiyang, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Jinan, China
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Jinan, China
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Kunming, China
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Kunming, China
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Lanzhou, China
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Nanchang, China
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Nanjing, China
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Nanning, China
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Ningbo, China
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Qingdao, China
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Shanghai, China
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Shenyang, China
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Shenyang, China
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Suining Shi, China
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Tianjin, China
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Wenzhou, China
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Wuhan, China
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Wuhan, China
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Xuzhou, China
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Zhengzhou, China
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Bordeaux, France
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Montpellier, France
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Paris, France
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Pierre-Bénite, France
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Poitiers, France
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Strasbourg, France
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Bochum, Germany
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Bonn, Germany
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Dresden, Germany
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Duisburg, Germany
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Frankfurt am Main, Germany
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Hamburg, Germany
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Hanover, Germany
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Herne, Germany
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Magdeburg, Germany
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Mannheim, Germany
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Marburg, Germany
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Mettmann, Germany
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Münster, Germany
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Nuremberg, Germany
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Nürtingen, Germany
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Regensburg, Germany
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Rostock, Germany
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Stuttgart, Germany
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Tübingen, Germany
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Ulm, Germany
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Kolkata, India
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Kottayam, India
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Nashik, India
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Navi Mumbai, India
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New Delhi, India
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New Delhi, India
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New Delhi, India
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Bari, Italy
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Florence, Italy
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Padova, Italy
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Roma, Italy
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Rozzano, Italy
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Tricase, Italy
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Fukuoka, Japan
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Fukuoka, Japan
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Hamamatsu, Japan
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Hirosaki-shi, Japan
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Kanazawa, Japan
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Kashihara-shi, Japan
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Kawasaki-shi, Japan
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Kita-gun, Japan
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Kobe, Japan
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Kōtoku, Japan
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Kumamoto, Japan
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Nagasaki, Japan
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Nagoya, Japan
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Osaka, Japan
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Osaka, Japan
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Toyama, Japan
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Tsukuba, Japan
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Gdansk, Poland
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Koszalin, Poland
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Poznan, Poland
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Siedlce, Poland
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Skórzewo, Poland
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Wroclaw, Poland
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Wroclaw, Poland
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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L'Hospitalet de Llobregat, Spain
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Las Palmas de Gran Canaria, Spain
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Madrid, Spain
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Santander, Spain
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Seville, Spain
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Kaohsiung City, Taiwan
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Kaohsiung City, Taiwan
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Kaohsiung City, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Hat Yai, Thailand
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Bristol, United Kingdom
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Cambridge, United Kingdom
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Preston, United Kingdom
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Sheffield, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/23/2026.
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