Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological Analyses
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This prospective study aims to characterize blood brain barrier (BBB) disruption in patients with newly diagnosed glioblastoma multiforme undergoing surgical resection. The study integrates advanced MRI, circulating BBB biomarkers, neurocognitive assessment, and molecular analysis of tumor tissue to investigate relationships between BBB integrity, tumor biology, and neurological function. Participants will undergo serial assessments before surgery, after surgery, and following radiotherapy. Tumor tissue collected during standard-of-care resection will undergo immunohistochemical and transcriptional
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Nowo zdiagnozowany glejak (guz mózgu)
- •Pacjent zakwalifikowany do operacyjnego usunięcia guza
- •Zdolność do podpisania zgody na uczestnictwo w badaniu
- •Możliwość przejścia badań i wizyt kontrolnych
✗ Disqualifies
- •Przeciwwskazania do badania MRI
- •Zaburzenia świadomości uniemożliwiające wyrażenie świadomej zgody
- •Inne stany mogące utrudnić udział w badaniu lub zagrażające bezpieczeństwu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 28, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Beaumont RCSI Cancer Centre
Beaumont, Ireland
Trial contact
Professor Donncha O'Brien, MB, BCh, BAO, MCh, FRCSI (SN)
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/29/2026.
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