Phase I Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Solid Tumors Like GBM and PDAC
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this Phase I clinical trial is to evaluate how the imaging drug 203Pb- RMX-VH-PIB distributes in the body and how much radiation different organs receive in patients with glioblastoma multiforme (GBM) or pancreatic ductal adenocarcinoma (PDAC). The main questions it aims to answer are: How does 203Pb-RMX-VH-PIB spread in the body (biodistribution)? What is the radiation dose delivered to organs (dosimetry)? Participants will: Receive a single IV injection of 203Pb-RMX-VH-PIB. Undergo multiple SPECT/CT imaging scans. Have blood, urine, vital signs, and ECG monitored for safety. Be followed for any side effects for up to 30 days.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wyrażona zgoda na udział w badaniu.
- •Osoby w wieku 18 lat i starsze.
- •Stan ogólny pozwalający na wykonywanie codziennych czynności (Karnofsky ≥60).
- •Wynik testu ciążowego u kobiet negatywny.
- •Potwierdzony guz mózgu (GBM) lub rak trzustki (PDAC).
- •Rozmiar guza co najmniej 1 cm.
- •Prawidłowe wyniki podstawowych badań krwi i funkcji nerek.
✗ Disqualifies
- •Uczulenie na lek lub jego składniki.
- •Niemożność wykonania badań obrazowych (MRI, CT/SPECT/CT).
- •Inne poważne choroby, które mogłyby wpłynąć na badanie.
- •Ciąża lub plany zajścia w ciążę w trakcie badania.
- •Uczulenie lub przeciwwskazania do stosowania środków kontrastowych używanych w badaniach MRI (dotyczy grupy z guzem mózgu).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 7, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Excel Diagnostics & Nuclear Oncology Center
Houston, United States
Trial contact
Ebrahim Delpassand, MD, FACNM
Izabela Tworowska, MSPharm, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/31/2026.
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