Protective Role of Alpha-Lipoic Acid in Chemotherapy-Induced Mucositis
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Colorectal cancer (CRC) represents one of the most common cancers worldwide and 5-Fluorouracil (5-FU) is still the mainstay of treatment. However, 5-FU is often implicated in inducing oral mucositis (OM), a painful inflammatory condition that may hinder oral intake, negatively impact quality of life and disrupt adherence with cancer treatment. Oxidative stress and inflammation play a vital role in OM pathogenesis. Alpha-lipoic acid (ALA) is a powerful antioxidant and anti-inflammatory agent that has demonstrated protective effects towards chemotherapy-induced mucosal damage in preclinical studies. Therefore, ALA may be a promising strategy to minimize or avoid 5-FU-induced oral mucositis in patients with colorectal cancer, which deserves additional clinical investigation.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Osoby powyżej 18 roku życia.
- •Pacjenci z nowo zdiagnozowanym rakiem jelita grubego, którzy nie byli wcześniej leczeni chemioterapią.
- •Pacjenci zakwalifikowani do leczenia protokołem FOLFOX-6.
- •Pacjenci z prawidłową czynnością wątroby i nerek.
- •Pacjenci z wystarczającą ilością prawidłowych komórek krwi.
✗ Disqualifies
- •Pacjenci z innymi chorobami nowotworowymi.
- •Pacjenci uczuleni na kwas alfa-liponowy.
- •Kobiety w ciąży lub karmiące piersią.
- •Pacjenci, u których wystąpiło już zapalenie błony śluzowej z innych przyczyn.
- •Pacjenci, którzy nie tolerują przyjmowania pokarmów doustnie.
- •Pacjenci przyjmujący inne suplementy antyoksydacyjne.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 30, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Nasser Institute for Research and Treatment.
Cairo, Egypt
Trial contact
Ghada Ramadan Youssef
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/31/2026.
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