Fecal Microbiota Transplantation for Obese Women With Polyendocrine Metabolic Ovarian Syndrome
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This single-center, prospective, two-stage clinical trial aims to evaluate the safety, preliminary efficacy, and reproductive outcomes of oral Fecal Microbiota Transplantation (FMT) freeze-dried capsules in overweight and obese patients with Polyendocrine Metabolic Ovarian Syndrome (PMOS) undergoing Frozen-Thawed Embryo Transfer (FET).The study is implemented in two sequential phases: Phase Ⅰ (Pilot Exploration): A prospective, open-label, single-arm exploratory study in an initial evaluable cohort ($n=11$) to evaluate preliminary safety, dynamic gut microbiota colonization, endocrine/metabolic parameters, and pregnancy outcomes following FET. Phase Ⅱ (Confirmatory RCT): A prospective, randomized controlled trial (RCT) designed to validate the clinical efficacy and underlying mechanisms of oral FMT capsules compared with control interventions, based on findings established in Phase Ⅰ.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Kobieta w wieku 20-40 lat
- •Diagnoza zespołu policystycznych jajników (PCOS)
- •Wskaźnik masy ciała powyżej 24 kg/m² (nadwaga lub otyłość)
- •Planowany transfer zamrożonego zarodka w klinice
- •Dobrowolna zgoda na udział w badaniu
✗ Disqualifies
- •Wiek poniżej 20 lub powyżej 40 lat
- •Ciąża lub karmienie piersią
- •Inne zaburzenia hormonalne lub poważne problemy z narządami
- •Antybiotyki, probiotyki lub prebiotyki w ciągu ostatniego miesiąca
- •Leki zmieniające owulację w ciągu ostatnich 3 miesięcy
- •Poważne zaburzenia psychiczne
- •Udział w innym badaniu klinicznym
Simplified criteria — AI translation
Trial details
- Minimum age
- 20 Years
- Maximum age
- 40 Years
- Last updated (source)
- August 12, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (1)
Center for Reproductive Medicine,Shanghai Changzheng Hospital
Shanghai, China
Trial contact
Ningxia Sun, Chief
Yichi Zhang, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/6/2026.
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