Diagnostic Accuracy of 18F-FDG PET/CT in Muscle-invasive Bladder Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
MIBC-PET is a prospective, monocentric, no-profit study with paired imaging comparison enrolling 60 patients with newly diagnosed, histologically confirmed high-grade MIBC. All patients undergo baseline staging with \[18F\]FDG PET/CT and contrast-enhanced CT (ceCT) of chest, abdomen, and pelvis. A second \[18F\]FDG PET/CT and CT are performed after two cycles of neoadjuvant therapy. \[18F\]FDG PET/CT includes both standard delayed imaging and an early dynamic pelvic acquisition to overcome urinary tracer interference. The primary endpoints are (1) diagnostic accuracy of \[18F\]FDG PET/CT versus ceCT for baseline staging, and (2) accuracy of \[18F\]FDG PET/CT in predicting pathological response to neoadjuvant chemotherapy. Secondary endpoints include validation of early dynamic \[18F\]FDG PET/CT for local staging and radiomic/AI-based predictive modeling.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Potwierdzony rozpoznaniem raka pęcherza moczowego naciekającego mięśnie
- •Kwalifikacja do chemioterapii opartej na platynie
- •Ogólny stan zdrowia pozwalający na leczenie (ECOG 0-1)
- •Prawidłowa funkcja nerek (klirens kreatyniny co najmniej 60 mL/min)
- •Brak powikłań, które uniemożliwiałyby chemioterapię
- •Możliwość wykonania badań obrazowych
- •Podpisana zgoda na uczestnictwo w badaniu
✗ Disqualifies
- •Wcześniejszy nowotwór w historii medycznej
- •Rak pęcherza nienaciekający mięśnie lub niskiego stopnia złośliwości
- •Niemożliwość wykonania badań z powodu klaustrofobii
- •Alergia na środek kontrastowy
- •Niekontrolowana cukrzyca
- •Poważne uszkodzenie nerwów lub słuchu
- •Poważne choroby serca
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 6, 2026
- Sex
- No restrictions
Locations (1)
Azienda Ospedaliero-Universitaria di Ferrara
Ferrara, Italy
Trial contact
Luca Urso, MD
Francesca Canella
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/7/2026.
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