A Study to Evaluate ATX-898 in Participants With Advanced Solid Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Study ATX-898-101 is a phase 1/2 open-label study evaluating the safety, tolerability, pharmacokinetic, and preliminary efficacy of ATX-898 as monotherapy and in combination with anti-neoplastic agents in selected solid tumors. This study consists of 2 parts. Part 1 evaluates ATX-898 as monotherapy and Part 2 evaluates ATX-898 in combination with anti-neoplastic agents of interest. Both parts will consists of a dose escalation portion and a dose expansion portion.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony zaawansowany nowotwór rozsiany lub niezdatny do operacji
- •Wiek minimum 18 lat
- •Ogólny stan zdrowia oceniony na 0 lub 1 w skali ECOG
- •Prawidłowe funkcje narządów wewnętrznych
- •Zgoda na biopsję nowotworu przed leczeniem lub dostępna próbka z ostatnich 5 lat
- •Wcześniejsze leczenie standardowe bez możliwości dalszej standardowej terapii
- •Potwierdzony status hormonalno-dodatni i HER2-ujemny (dla części 2)
- •Co najmniej jedna mierzalna zmiana nowotworowa
✗ Disqualifies
- •Inne nowotwory w ciągu ostatnich 2 lat przed badaniem
- •Przerzuty do mózgu z objawami lub wymagające sterydów
- •Nieprzezwyciężone skutki uboczne poprzednich terapii
- •Zapalenie opon mózgowych lub inne warunki uniemożliwiające uczestnictwo
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (6)
START Dallas Fort Worth Cancer Center
Fort Worth, United States
MD Anderson Cancer Center
Houston, United States
START San Antonio Cancer Center
San Antonio, United States
START Mountain Region Cancer Center
West Valley City, United States
NEXT Virginia Cancer Center- Merrifield Tech Center
Fairfax, United States
Linear Clinical Research
Perth, Australia
Trial contact
Antares Medical Monitor
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/17/2026.
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