Understanding New Cachexia Subtypes Through Observational Epidemiological Research
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The UNCOVER study is a longitudinal observational cohort focused on patients at high risk for cancer cachexia. At Kaiser Permanente Northern California, up to 800 individuals with advanced or unresectable non-small cell lung cancer, pancreatic adenocarcinoma, or colorectal cancer will be enrolled, as these malignancies carry a substantial risk of cancer cachexia, which is characterized by progressive loss of weight, muscle, and adipose tissue, accompanied by functional decline and reduced quality of life. Data collected includes demographic, physiologic, and clinical data, including tumor characteristics and biomarkers of inflammation, hormonal and metabolic status, body composition, physical function, and patient reported outcomes. Investigators will identify patient phenotypes (i.e., subgroups) that may reflect distinct biological or clinical pathways underlying cancer cachexia. By characterizing heterogeneity in cancer cachexia, this study aims to inform the development of improved diagnostic criteria and more targeted therapeutic strategies, ultimately enhancing clinical trial design and supportive care for patients with advanced colorectal, lung, or pancreatic cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Zdiagnozowany zaawansowany lub nieoperowalny rak płuca (typ niedrobnokomórkowy), rak trzustki lub rak jelita grubego
- •Planujesz rozpocząć lub już rozpocząłeś pierwszą linię leczenia (chemioterapia, immunoterapia) w ciągu ostatnich 6 tygodni
- •Zdolność do wykonywania testów sprawności fizycznej
- •Wiek 18 lat lub więcej
- •Umiejętność czytania, mówienia i rozumienia po angielsku
✗ Disqualifies
- •Zaplanowana poważna operacja chirurgiczna w ciągu 3 miesięcy od włączenia do badania
- •Chemioterapia lub operacja z powodu innego nowotworu w ostatnich 3 latach (oprócz raka skóry)
- •Ciąża lub okres do 6 miesięcy po porodzie
- •Przeciwwskazania medyczne do testów sprawności fizycznej
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 20, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Kaiser Permanente Northern California
Pleasanton, United States
Trial contact
Elizabeth M Cespedes Feliciano, ScD, SM
Michelle C Ross, MPH
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/21/2026.
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