Physical Activity and Healthy Aging: Promoting Cardio-metabolic Capacity to Fight Chronic Inflammation and Improve Outcomes in Breast Cancer Patients (PhActHealth Study)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
PhActHealth is a multicenter randomized controlled trial enrolling women with newly diagnosed luminal B or triple-negative breast cancer (BC) who are candidates for neoadjuvant therapy. The study aims to investigate the effects of a preoperative, unsupervised exercise training program on exercise capacity, as well as on immune response, autonomic nervous system (ANS) regulation, cardiovascular health, and tumor aggressiveness prior to surgical removal. Participants are randomly assigned to either an intervention group or a control group. All patients receive lifestyle counseling, while those in the intervention group additionally follow a personalized aerobic and resistance exercise program throughout the neoadjuvant treatment period before surgery. The primary outcome is the improvement in exercise capacity. The secondary outcomes are tumor-specific and systemic responses to the intervention, evaluated by analyzing molecular, metabolic, and inflammatory markers, as well as clinical and functional parameters.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Nowo rozpoznany rak piersi (typ luminalno B lub potrójnie ujemny)
- •Kwalifikacja do chemioterapii lub immunoterapii przed operacją
- •Podpisana zgoda na udział w badaniu
- •Brak regularnej aktywności fizycznej lub sportów konkurencyjnych
✗ Disqualifies
- •Przewlekłe choroby (zakaźne, neurodegeneracyjne, psychiatryczne)
- •Warunki uniemożliwiające ćwiczenia
- •Ciąża, karmienie piersią lub plany zajścia w ciążę
- •Chemioterapia lub immunoterapia w ciągu ostatnich 3 lat
- •Już wysoka aktywność fizyczna (powyżej 600 MET minut tygodniowo)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 20, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (2)
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy
University of Urbino "Carlo Bo"
Urbino, Italy
Trial contact
Elia M Biganzoli, Professor
Roberta Biciuffi, MSc
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/21/2026.
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