Becotatug Vedotin Combined With a PD-1 Inhibitor in the Treatment of Locally Advanced Recurrent Nasopharyngeal Carcinoma.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study plans to enroll patients with histologically or cytologically confirmed locally recurrent nasopharyngeal carcinoma. After signing informed consent, eligible subjects will receive three cycles of standard-dose becotatug vedotin combined with a PD-1 inhibitor. Following treatment, imaging assessment and surgical evaluation will be performed. Subjects deemed operable will undergo endoscopic nasal surgery, after which the MDT (multidisciplinary team) will discuss and determine a maintenance treatment plan. For subjects who are not eligible for surgery, the MDT will decide on either maintenance therapy or a switch to an alternative treatment regimen.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony diagnozy nawrotu raka nosogardła (w lokalizacji pierwotnej i/lub węzłach chłonnych)
- •Brak przerzutów odległych
- •Co najmniej jeden guz widoczny w badaniach obrazowych (CT lub MRI)
- •Dobry stan ogólny (ECOG 0-1)
- •Przewidywana długość życia co najmniej 3 miesiące
- •Prawidłowa funkcja narządów wewnętrznych
- •U kobiet w wieku rozrodczym: ujemny test na ciążę
✗ Disqualifies
- •Inny nowotwór zdiagnozowany w ciągu ostatnich 5 lat (poza zmianami skórnymi)
- •Poprzednie leczenie lekami z grupy ADC zawierającymi MMAE
- •Aktywne krwawienie z guza potwierdzone endoskopowo
- •Uczestnictwo w innym badaniu klinicznym w ciągu ostatnich 4 tygodni
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 80 Years
- Last updated (source)
- August 24, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Eye and ENT Hospital of Fudan University
Shanghai, China
Trial contact
Li Yan, MD
Xiaole Song, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/25/2026.
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