Blood-Brain Barrier Disruption Using Exablate Magnetic Resonance-Guided Low Intensity Focused Ultrasound With Microbubbles in Combination With T-Cell Infusion in Patients With Newly Diagnosed Diffuse Midline Glioma (LIFT)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is an open-label phase 1 safety and feasibility study evaluating a novel combination therapy for Diffuse Midline Glioma (DMG), an aggressive brain tumor with a very poor prognosis - an average one-year overall survival. This study combines blood-brain barrier (BBB) disruption (BBBD) using low-intensity focused ultrasound (LIFU) and microbubble treatment, and intravenous infusion of autologous, tumor multi-antigen associated specific cytotoxic T lymphocyte (TAA-T) therapy. The TAA-T cell investigational product in this protocol is manufactured to target Preferentially Expressed Antigen of Melanoma (PRAME), Wilms Tumor 1 (WT1), and survivin.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek od 3 do 25 lat
- •Rozpoznanie glejaka pnia mózgu lub wzgórza (DMG)
- •Ukończona standardowa radioterapia
- •Pierwsze pobranie krwi od 4 do 14 tygodni (grupa A) lub 4 do 22 tygodni (grupa B) po zakończeniu radioterapii
- •Stan ogólny dziecka na poziomie pozwalającym na aktywność lub opiekę (wynik Lansky'ego ≥60)
- •Obwód głowy co najmniej 49 cm
- •Waga co najmniej 10 kg
- •Prawidłowe wyniki badań krwi i funkcji narządów (hemoglobina, białe krwinki, płytki, wątroba, nerki, tlen we krwi)
Simplified criteria — AI translation
Trial details
- Minimum age
- 3 Years
- Maximum age
- 25 Years
- Last updated (source)
- October 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Children's National Hospital
Washington D.C., United States
Trial contact
Luca Szalontay, MD
Fahmida Hoq, MBBS
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/8/2026.
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