Guaraná Supplementation for Cancer-Related Fatigue
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Cancer-related fatigue is one of the most common and distressing symptoms experienced by patients during and after cancer treatment, and current options to manage it are limited. Guaraná (Paullinia cupana), an Amazonian plant rich in caffeine and other methylxanthines with anti-inflammatory and central-nervous-system-stimulating properties, has shown preliminary benefit for fatigue in small studies but lacks robust evidence. This pragmatic, prospective, single-arm study will evaluate whether guaraná supplementation reduces chronic cancer-related fatigue and improves quality of life in 60 patients with breast, lung, colorectal, or gastric cancer receiving active systemic treatment. Participants will take a 50 mg guaraná capsule by mouth every 12 hours for up to six 21-day cycles. The main outcome is the change in fatigue (baseline vs. post-intervention) measured with the FACIT-F and the Brief Fatigue Inventory (BFI). Secondary outcomes include quality of life (EORTC QLQ-C30) and adverse events. The study aims to support guaraná as a safe, accessible complementary option in supportive cancer care.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowotwór: rak piersi, płuc, jelita grubego, szyjki macicy lub żołądka
- •Aktualnie odbywające się leczenie przeciwnowotworowe
- •Ukończone co najmniej 3 cykle chemioterapii
✗ Disqualifies
- •Nietolerancja guarany lub kofeiny
- •Problemy z sercem: niekontrolowana arytmia, szybkie bicie serca lub zaburzenia rytmu
- •Przyjmowanie leków przeciwkrzepliwych (warfaryna)
- •Przyjmowanie innych pobudlików ośrodkowego układu nerwowego
- •Ostatnia historia krwawień
- •Przyjmowanie teodyliny
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 11, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Fundación CTIC Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo
Bogotá, Colombia
Trial contact
Liliana Gutiérrez, RN, MSc
Briegel De Las Salas, Microb, MSc
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/12/2026.
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