Multimodal Prehabilitation in Gastric Cancer Patients
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This single-arm phase II trial investigates whether a multimodal prehabilitation program can attenuate the postoperative inflammatory response in patients undergoing curative gastric cancer surgery. Major abdominal surgery induces a pronounced systemic inflammatory reaction that contributes to postoperative complications, delayed recovery, impaired functional status, and reduced tolerance to adjuvant therapy. Elevated postoperative C-reactive protein (CRP) trajectories have been associated with infectious complications, whereas a timely decline in CRP may reflect a more adequate immune response. Interventions that improve nutritional status, physical fitness, and psychological resilience before surgery may modulate these inflammatory processes. The PING-P intervention combines three components starting two weeks before surgery and continuing for three weeks postoperatively: (1) structured exercise including resistance, aerobic and respiratory training supported by pulsed electromagnetic field (PEMF) therapy to both thighs twice weekly; (2) individualized nutritional therapy with counseling and provision of omega-3-enriched high-protein oral nutritional supplements twice daily to achieve ≥1.2 g/kg/day protein intake; and (3) psychological support using coaching and digital relaxation tools. The program is delivered in hospital and at home using a mobile application with regular monitoring and feedback. The primary objective is to evaluate whether this multimodal approach reduces the proportion of patients with a poor postoperative immune response, defined as either a CRP peak ≥166 mg/L or a decrease from peak CRP to two days later of \<35%. CRP will be measured from postoperative day (POD) 1 to POD7 or until discharge. Secondary objectives include assessment of feasibility (recruitment, retention, and adherence to ONS intake, PEMF sessions, and exercises), postoperative infectious and overall complications, intervention-related adverse events, functional recovery, nutritional status, body composition, and quality of life. Adults with histologically proven gastric or esophagogastric junction cancer (Siewert II-III) scheduled for minimally-invasive curative gastrectomy at National University Hospital and Ng Teng Fong General Hospital, Singapore, will be enrolled. Exclusion criteria include distant metastases, emergency surgery, need for preoperative tube or parenteral feeding, inability to follow the program, or contraindications to oral nutrition. A total of 25 participants will be recruited. The study will provide first data on whether targeted multimodal prehabilitation can favorably modify perioperative inflammation and inform the design of a future randomized trial.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Osoby w wieku od 22 do 99 lat.
- •Potwierdzony rak żołądka lub połączenia przełykowo-żołądkowego.
- •Planowana operacja mająca na celu całkowite usunięcie guza.
- •Brak przerzutów do innych narządów.
- •Możliwość samodzielnego spożywania posiłków.
- •Zgoda na udział w badaniu i możliwość stosowania się do zaleceń w domu.
✗ Disqualifies
- •Problemy z pamięcią, demencja lub choroby psychiczne, które uniemożliwiają wyrażenie zgody lub stosowanie się do zaleceń.
- •Nagła operacja lub zmiana planów podczas operacji.
- •Potrzeba specjalistycznego odżywiania przed operacją.
- •Ciężkie choroby współistniejące wymagające usunięcia wielu narządów.
- •Alergia lub nietolerancja na składniki podawanego suplementu diety.
- •Ciężkie problemy z poruszaniem się, które utrudniają ćwiczenia.
- •Pacjenci objęci opieką paliatywną lub odrzucający leczenie przyczynowe.
Simplified criteria — AI translation
Trial details
- Minimum age
- 22 Years
- Maximum age
- 99 Years
- Last updated (source)
- September 24, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
National University Hospital
Singapore, Singapore
Trial contact
Jimmy Bok Yan So, Prof.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/25/2026.
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