Prevention of Bile Leakage After Liver Resection in Children
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Bile leakage is a clinically important complication after liver resection in children and may require prolonged drainage, additional radiological or endoscopic procedures, or repeat surgery. The risk may be particularly high in patients with tumors adjacent to the hilar plate of the future liver remnant and tumors involving three adjoining liver sections. This prospective, single-center, open-label interventional study will enroll 12 children and adolescents aged 0 to 18 years who are undergoing liver resection and are considered to have a high risk of postoperative bile leakage. All participants will undergo prophylactic extrahepatic biliary drainage during liver resection. The study hypothesis is that prophylactic biliary drainage will reduce the incidence of bile leakage within 90 days after surgery compared with a prespecified historical cohort of high-risk patients treated at the same center. Participants will be followed for 90 days after liver resection. The primary outcome is the incidence of bile leakage during this period. Secondary outcomes include unsuccessful biliary drainage attempts, intraoperative complications, postoperative complications, and serious complications.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek od urodzenia do 18 lat
- •Guz wątroby potwierdzony badaniami krwi i obrazowaniem
- •Konieczność operacyjnego usunięcia części wątroby
- •Guz dotykający lub przylegający do przewodów żółciowych pozostałej wątroby
- •Potwierdzenie w tomografii wykonanej maksymalnie 28 dni przed operacją
- •Zgoda rodziców lub opiekunów prawnych oraz dziecka (jeśli jest w stanie wyrazić zgodę)
✗ Disqualifies
- •Guz naciekający zewnętrzne przewody żółciowe
- •Wcześniejszy drenaż żółci przed tą operacją
- •Wcześniejsza operacja usunięcia części wątroby
- •Brak prawidłowego badania tomografii w ciągu 28 dni przed operacją
Simplified criteria — AI translation
Trial details
- Minimum age
- 0 Years
- Maximum age
- 18 Years
- Last updated (source)
- October 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
Moscow, Russia
Trial contact
Dmitry G Akhaladze, MD, PHD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/10/2026.
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